Heparanase : From Basic Research to Clinical Applications /: From Basic Research to Clinical Applications. (2020)

• Record Type: Book
• Further Information: Note: Israel Vlodavsky, Ralph D. Sanderson, Neta Ilan.
• Editors: Vlodavsky, Israel; Sanderson, Ralph D; Ilan, Neta
• Contents: Historical background 1. Mast cell/platelet heparanase/Heparan sulfate biosynthesis and turnover 2. Gene cloning/overview 3. Gene cloning/melanoma metastasis 4. Gene cloning/cancer/immune system 5. Heparin/HS modifying enzymes Crystal structure/substrate specificity/gene regulation 6. Crystal structure 7. Molecular dynamics, KKDC peptide 8. Biochemistry/active site 9. Substrate specificity 10.Gene regulation, promoter/Egr1/methylation 11. SNPs - polymorphism 12. Splice variants Cell & tumor biology (general functions & mode of action) 13 Exosomes/heparan sulfate/heparanase 14. Exosomes/drug resistance 15. Nuclear heparanase/transcriptional activity 16. Non-enzymatic functions/signal transduction/cellular trafficking/autophagy 17. Heparan sulfate/stem cells/inflammation 18. Danger signals/HS/platelet heparanase 19. Heparanase/integrins/melanoma Immune cells/immuno-modulation 20. Heparin, heparanase & selectins in cancer metastasis and inflammation 21Trans-endithelial migration, lymphocytes/neutrophils/t-cells 22 Macrophages/ dendritic cells/autoimmunity 23. Macrophages, Heparanase and the tumor microenvironment, neutralizing antibodies 24. NK cells Cancer (heparanase in specic types of cancer) 25. Myeloma/inhibition/drug resistance 26. Breast cancer/pancreatic cancer/Cancer & Inflammation 27 Brain metastasis/mir-1258 28. Gastric cancer/immunization 29. Head & Neck 30. Glioma 31.Sarcoma Inhibitors/clinical trials/cancer 32. Chemistry/synthesis of heparanase inhibitors PI-88, PG 33. PG series; biology. Tumor models & clinical trial 34 Chemically modified heparins/ Heparin mimetics 35. Roneparstat/small molecules/clinical trials Other indications/diseases 36.IBD/inflammation & cancer/diabetes/obesity 37 immune diabetes 38. Inflammation, Sepsis/Amyloidosis 39. Kidney dysfunction 40. Fibrosis 41. Viral infection 42. Cariomyocytes/ Endothelial cell-cardiomyocyte crosstalk in diabetic cardiomyopathy 43. Eye research 44. Atherosclerosis, nuclear localization 45. Coagulation/tissue factor Heparanase-2 (Hpa2) 46. Hpa2 gene cloning 47. UFS - urofacial syndrome; peripheral neuropathy 48. Hpa2: tumor suppressor.
• Publisher Details: Cham : Springer
• Publication Date: 2020
• Copyright Date: 2020
• Extent: 1 online resource (885 pages)
• Subjects: Medicine; Cancer research; Oncology ; Molecular biology; Medical -- Oncology; Science -- Life Sciences -- Biology -- Molecular Biology; Oncology; Medical research
• Languages: English
• ISBNs: 9783030345211
• Related ISBNs: 9783030345204
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.