Drug delivery in oncology. from basic research to cancer therapy /: from basic research to cancer therapy. Volume 1 : (©2012)

• Record Type: Book
• Further Information: Note: Edited by Felix Kratz, Peter Senter, and Henning Steinhagen.
• Other Names: Kratz, Felix; Kratz, Felix; Senter, Peter; Steinhagen, Henning; Wiley InterScience (Online service)
• Contents: Cover; Related Titles; Title Page; Copyright; Foreword; Preface; List of Contributors; Drug Delivery in Oncology -- Challenges and Perspectives; Part I: Principles of Tumor Targeting; Chapter 1: Limits of Conventional Cancer Chemotherapy; 1.1 Introduction: The Era of Cancer Chemotherapy; 1.2 Dilemma and Challenge of Treating Malignant Diseases; 1.3 Adverse Effects; 1.4 Supportive Care; 1.5 New Approaches Complementing Current Cancer Chemotherapy; 1.6 Conclusions and Perspectives; References; Chapter 2: Pathophysiological and Vascular Characteristics of Solid Tumors in Relation to Drug Delivery. 2.1 Introduction2.2 Basic Principles of Blood Vessel Formation in Solid Tumors; 2.3 Tumor Lymphangiogenesis; 2.4 Tumor Vascularity and Blood Flow; 2.5 Arteriovenous Shunt Perfusion in Tumors; 2.6 Volume and Characteristics of the Tumor Interstitial Space; 2.7 Interstitial Fluid Pressure in Tumors; 2.8 Role of the Disorganized, Compromised Microcirculation as an Obstacle in Drug Delivery; 2.9 Interstitial Barriers to Drug Delivery; 2.10 Pathophysiological Tumor Microenvironment as an Obstacle in Tumor Therapy; 2.11 Conclusions; References; Acknowledgments. Chapter 3: Enhanced Permeability and Retention Effect in Relation to Tumor Targeting3.1 Background and Status Quo; 3.2 What is the EPR Effect: Mechanism, Uniqueness, and Factors Involved; 3.3 Heterogeneity of the EPR Effect: A Problem in Drug Delivery; 3.4 Overcoming the Heterogeneity of the EPR Effect for Drug Delivery and How to Enhance the EPR Effect; 3.5 PEG Dilemma: Stealth Effect and Anti-PEG IgM Antibody; 3.6 Concluding Remarks; References; Acknowledgments; Chapter 4: Pharmacokinetics of Immunoglobulin G and Serum Albumin: Impact of the Neonatal Fc Receptor on Drug Design. 4.1 Introduction4.2 Discovery of FcRn; 4.3 FcRn Structure; 4.4 FcRn-Ligand Interactions; 4.5 FcRn as a Multiplayer with Therapeutic Utilities; 4.6 Engineering IgG for Altered FcRn Binding and Pharmacokinetics; 4.7 Targeting FcRn by SA; 4.8 Considering Cross-Species Binding; 4.9 Concluding Remarks; References; Acknowledgment; Chapter 5: Development of Cancer-Targeting Ligands and Ligand-Drug Conjugates; 5.1 Introduction; 5.2 Overview of Cancer-Targeting Ligand-Drug Conjugates; 5.3 Cancer-Targeting Ligands; 5.4 Linkers; 5.5 Examples of Cancer-Targeting Ligand-Drug Conjugates. 5.6 Conclusions and PerspectivesReferences; Acknowledgments; Chapter 6: Antibody-Directed Enzyme Prodrug Therapy (ADEPT) -- Basic Principles and its Practice So Far; 6.1 Introduction; 6.2 Principles and the Components of ADEPT; 6.3 Third Essential; 6.4 ADEPT Studies Elsewhere; 6.5 Reagents for First Clinical Trials in London (1990-1995); 6.6 Technology Advances; 6.7 ADEPT Future; References; Part II: Tumor Imaging; Chapter 7: Imaging Techniques in Drug Development and Clinical Practice; 7.1 Introduction; 7.2 Cancer Biology; 7.3 Cancer Biomarkers; 7.4 Imaging Techniques.
• Publisher Details: Weinheim : Wiley-VCH
• Publication Date: 2012
• Copyright Date: 2012
• Extent: 1 online resource (2626 pages)
• Subjects: 616.994061; Cancer -- Chemotherapy; Drug delivery systems; Cancer -- Chemotherapy; Drug delivery systems; Càncer -- Quimioteràpia; Medicaments -- Modes d'administració; Electronic books
• Languages: English
• ISBNs: 3527647759; 9783527647750; 3527647767; 9783527647767; 3527634053; 9783527634057
• Related ISBNs: 9783527328239
• Notes: Note: Includes bibliographical references and index.; Note: Print version record.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.