Monolithic silicas in separation science : concepts, syntheses, characterization, modeling and applications /: concepts, syntheses, characterization, modeling and applications. (2010)

• Record Type: Book
• Further Information: Note: Edited by Klaus K. Unger, Nobuo Tanaka, Egidijus Machtejevas.
• Other Names: Unger, K. K (Klaus K.), 1936-; Tanaka, Nobuo, 1949-; Machtejevas, Egidijus
• Contents: Preface; THE BASIC IDEA AND THE DRIVERS; Definitions; Monoliths as Heterogeneous Catalysts; Monoliths in Chromatographic Separations; Conclusion and Perspectives; ; PART I: Preparation; ; SYNTHESIS CONCEPTS AND PREPARATION OF SILICA MONOLITHS; Introduction; Background and Concepts; Synthesis of Silica Monoliths; Monolithic Columns Prepared in the Laboratory; PREPARATION AND PROPERTIES OF VARIOUS TYPES OF MONOLITHIC SILICA STATIONARY PHASES FOR REVERSED-PHASE, HYDROPHILIC INTERACTION, AND ION-EXCHANGE CHROMATOGRAPHY BASED ON POLYMER-COATED MATERIALS; Stationary Phases for Reversed-Phase Chromatography; Stationary Phases for Hydrophilic-Interaction Chromatography Separations; Stationary Phases for Ion-Exchange Separations; Advantages of Polymer-Coated Monolithic Silica Columns; ; PART II: Characterization and Modeling; ; CHARACTERIZATION OF THE PORE STRUCTURE OF MONOLITHIC SILICAS; Monolithic Silicas; General Aspects Describing Porous Materials; Characterization Methods of the Pore Structure of Monolithic Silicas; Comparison of the Silica Monolith Mesopore-Characterization Data; Comparison of the Silica Monolith Flow-Through Pore-Characterization Data; MICROSCOPIC CHARACTERIZATIONS; Introduction; Preparation of Macroporous Silica Monolith; Laser Scanning Confocal Microscope Observation; Image Processing; Fundamental Parameters; Three-Dimensional Observation of Deformations in Confined Geometry; MODELING CHROMATOGRAPHIC BAND BROADENING IN MONOLITHIC COLUMNS; Introduction; The General Plate-Height Model; User of the General Plate-Height Model to Predict Band Broadening in TSM Structures; Conclusion; COMPARISON OF THE PERFORMANCE OF PARTICLE-PACKED AND MONOLITHIC COLUMNS IN HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY; Introduction; Basic Columns Properties; Comparison of the Through-Pore Structures and Related Properties; Thermodynamic Properties; Kinetic Properties and Column Efficiency; Conclusions; ; PART III: Applications; ; QUANTITATIVE STRUCTURE-RETENTION RELATIONSHIPS IN STUDIES OF MONOLITHIC MATERIALS; Fundamentals of Quantitative Structure-Retention Relationships (QSSR); Quantitative Relationships between Analyte Hydrophobicity and Retention on Monolithic Columns; QSSR Based on Structural Descriptors from Calculation Chemistry; LSER on Monolithic Columns; Concluding Remarks; PERFORMANCE OF SILICA MONOLITHS FOR BASIC COMPOUNDS. SILANOL ACTIVITY; Introduction; Reproducibility of Commercial Monoliths for Analysis of Bases; Activity of Monoliths towards Basic Solutes; Contribution of Overload to Peak Shapes of Basic Solutes; Van Deemter Plots for Commercial Monoliths; Performance of Hybrid Capillary Silica Monoliths for Basic Compounds; QUALITY CONTROL OF DRUGS; Introduction; Analysis of Pharmaceutics; Natural Products Analysis; Analysis Speed and Performance; Method Transfer; Separation of Complex Mixtures; Monolithic Derivatives and Versatile Application; Summary and Conclusions; MONOLITHIC STATIONARY PHASES FOR FAST ION CHROMATOGRAPHY; Fast Ion Chromatography; Historical Development of Fast Ion Chromatography; 3 Advantages of the Bimodal Porous Structure of the Silica Monolith Matrix; Type and Properties of Silica Monolithic Columns Used in IC; Modification of Silica Monoliths for IC Separations; Operational Parameters; Analytical Applications; Future Work; MONOLITHIC CHIRAL STATIONARY PHASES FOR LIQUID-PHASE ENANTIOSEPARATION TECHNIQUES; Introduction; Organic Monolithic Materials for the Separation of Enantiomers; Silica-Based Monolithic Materials for the Separation of Enantiomers; Summary of the Present State-of-the-Art and Problems to be Solved in the Future; HIGH-SPEED AND HIGH-EFFICIENCY SEPARATIONS BY UTILIZING MONOLITHIC SILICA CAPILLARY COLUMNS; Introduction; Preparation of Monolithic Silica Capillary Columns; Properties of Monolithic Silica Capillary Columns; Monolithic Silica Capillary Columns for High-Efficiency Separations; Monolithic Silica Capillary Columns for High-Speed Separations; Future Considerations; SILICA MONOLITHIC COLUMNS AND MASS SPECTROMETRY; Introduction; Offline Chromatography, LC MALDI MS; Online ESI LC/MS/MS for Proteomics and Selected Reaction Monitoring (SRM); Online Reactors and Affinity Columns Coupled to Mass Spectrometry; Conclusion; SILICA MONOLITHS FOR SMALL-SCALE PURIFICATION OF DRUG-DISCOVERY COMPOUNDS; Introduction; Instrumental and Operating Considerations; Preparative Separations and Sample Loading; Purification of Drug-Discovery Compounds; Conclusions; MONOLITHIC SILICA COLUMNS IN MULTIDIMENSIONAL LC-MS FOR PROTEOMICS AND PEPTIDOMICS; Introduction; Liquid Chromatography as a Tool Box for Proteomics; Selectivity of Columns for MD-LC; Dimensions of Columns in MD-LC; Monolithic Silica Columns; Applications of Monolithic Silica in Proteomics -; A Brief Survey; Summary and Conclusions; SILICA MONOLITHS IN SOLID-PHASE EXTRACTION AND SOLID-PHASE MICROEXTRACTION; Introduction; Extraction Process; Extraction Platforms; Applications; Conclusion and Outlook;
• Publisher Details: Place of publication not identified : Wiley-VCH
• Publication Date: 2010
• Extent: 1 online resource (362 pages)
• Subjects: 546.683; Silica; Separation (Technology)
• Languages: English
• ISBNs: 9783527633265
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.