Tumor microenvironment : the main driver of metabolic adaptation /: the main driver of metabolic adaptation. (©2020)

• Record Type: Book
• Further Information: Note: Jacinta Serpa, editor.
• Authors: Serpa, Jacinta
• Editors: Serpa, Jacinta
• Contents: Preface -- Tumor microenvironment a job of several holders -- Tumor microenvironment- a selective pressure boosting cancer -- Lactate and lactate transporters as key players in the maintenance of the Warburg effect -- Section 1. Adaptive metabolic features are sustained by tumor microenvironment -- Recycling the interspecific relations with epithelial cells: bacteria and cancer metabolic symbiosis -- Gut microbiota and cancer of the host: colliding interests -- Metabolic plasticity of tumor cells: how they do adapt to food deprivation -- Multifaceted oncogenic role of adipocytes in the tumour microenvironment -- Endothelial cells (ECs) metabolism a valuable piece to disentangle cancer biology -- Monocytes and macrophages in cancer: unsuspected roles -- Section 2. Microenvironment and metabolic signalling- the way cancer cells know how to survive.-: Wnt signaling: paths for cancer progression -- Microenvironment driven metabolic adaptation in melanoma -- Metabolic reprogramming and signaling to chromatin modifications in tumorigenesis -- Inflammatory microenvironment modulation of alternative splicing in cancer: a way to adapt -- The bone marrow niche -- the tumor microenvironment that ensures leukemia progression -- Section 3. Metabolic fitness and therapy response in cancer -- Exploiting cancer cells metabolic adaptability to enhance therapy response in cancer -- The metabolic remodelling in lung cancer and its putative consequence in therapy response -- Hydrogen sulfide metabolism and signaling in the tumor microenvironment -- Using metabolic adaptation to design new drugs -- Metabolomics- a new way of screening cancer -- NMR as a tool for metabolomics -- Section 5. Animal models- addressing cancer microenvironment -- Animal models to study cancer and its microenvironment -- Modulating the metabolic phenotype of cancer microenvironment -- Modeling of Solid-tumor Microenvironment in Zebrafish (Danio Rerio) Larvae -- Section 6. In vitro and ex vivo cancer models -- In vitro and ex vivo models- the tumor microenvironment in a flask -- Index.
• Publisher Details: Cham : Springer
• Publication Date: 2020
• Copyright Date: 2020
• Extent: 1 online resource
• Subjects: 571.9/78; Tumors -- Metabolism; Cancer cells -- Growth; Cancer cells -- Adaptation; Cancer cells -- Adaptation; Cancer cells -- Growth; Electronic books
• Languages: English
• ISBNs: 9783030340254; 3030340252; 9783030340261; 3030340260; 9783030340278; 3030340279
• Related ISBNs: 3030340244; 9783030340247
• Notes: Note: Includes bibliographical references.; Note: Online resource; title from PDF title page (SpringerLink, viewed April 1, 2020).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.