Tau biology. ([2019])

• Record Type: Book
• Further Information: Note: Akihiko Takashima, Benjamin Wolozin, Luc Buee, editors.
• Editors: Takashima, Akihiko; Wolozin, Benjamin; Buee, Luc
• Contents: 1) Structure and role of Tau molecule.- (1) Tau structure in solution: FRET study.- (2) Tau structure in solution: NMR study.- (3) Structure of NFT: Biochemical approach.- (4) Structure of NFT: CryoEM approach.- (5) MAPT tau gene and FTDP-17 mutation.- (6) Tau phosphorylation.- (7) Tau acetylation.- (8) Tau truncation.- (9) Tau interacted proteins: interactome.- (10) Tau clearance mechanism.- 2) Tau localization and function.- (11) Localization of Tau.- (12) Axonal transport.- (13) Synaptic localization of tau.- (14) Role of tau in synapse.- (15) Tau in nucleus and nucleic acids.- (16) Tau and the translational stress response.- 3) Tauopathies; pathology, drivers, and marker.- (17) Tau pathology with aging.- (18) Clinical symptom and pathology of FTD including FTDP-17.- (19) Chronic Traumatic Encephalopathy.- (20) Myotonic dystrophies.- (21) Tau PET.- (22) Tau PET/connectome/fMRI.- (23) Stress.- (24) Diabetes.- (25) Relationship between ApoE and tau.- (26) Relationship between Ab and tau.- 4) Tau aggregation, and therapy.- (27) Tau Oligomer.- (28) Tau droplet formation.- (29) Stress granule.- (30) Tau secretion.- (31) Tau seeding.- (32) Prion-like Tau propagation.- (33) Experimental models for tauopathies.- (34) Dementia therapy targeting tau.- (35) Tau aggregation inhibitor.
• Publisher Details: Singapore : Springer
• Publication Date: 2019
• Extent: 1 online resource
• Subjects: 612.01575; Nerve tissue proteins; Electronic books
• Languages: English
• ISBNs: 9789813293588; 9813293586
• Related ISBNs: 9813293578; 9789813293571
• Notes: Note: Description based on online resource; title from digital title page (viewed on March 13, 2020).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.