Breast cancer in young women. ([2020])

• Record Type: Book
• Further Information: Note: Oreste Gentilini, Ann H. Partridge, Olivia Pagani, editors.
• Editors: Gentilini, Oreste Davide; Partridge, Ann (Ann H.); Pagani, Olivia
• Contents: Intro -- Contents -- Contributors -- 1: Epidemiology -- 1.1 Incidence and Time Trends -- 1.2 Risk Factors -- 1.2.1 Reproductive and Hormonal Factors -- 1.2.2 Health Behaviors and Environmental Factors -- 1.2.3 Race -- 1.2.4 Genetic Risk Factors -- 1.3 Features of Breast Cancer in Young Women -- 1.3.1 Stage, Grade, and Tumor Subtypes -- 1.3.2 Independent Risk of Young Age -- 1.3.3 Unique Treatment -- 1.3.4 Adherence -- 1.4 Special Considerations for Young Women -- 1.5 Summary -- References -- 2: Young Age and Breast Cancer Biology -- 2.1 Introduction 2.2 Gene Expression Profiling -- 2.2.1 Enrichment of Basal-Like Tumors in Young Women -- 2.2.2 Unique Transcriptomic Alterations in Young Women -- 2.3 Germline BRCA Mutation and the Interplay with PgR and RANKL Signaling -- 2.3.1 Germline BRCA Mutation in Young Breast Cancer Patients -- 2.3.2 PgR and BRCA Crosstalk -- 2.3.3 RANKL Regulates PgR Signaling and Is Implicated in BRCA-Related Tumors -- 2.4 Copy Number Alterations According to Age -- 2.5 Higher Frequency of GATA3 Mutations in Young Women with Breast Cancer -- 2.6 Pregnancy Modulates Breast Cancer Biology 2.7 Translating Biological Knowledge into Improving Patient Care -- References -- 3: Imaging to Improve Diagnosis of Breast Cancer in Young Women -- 3.1 Introduction -- 3.2 Specific Imaging Characteristics in Young Women with Breast Cancer -- 3.3 Breast Density -- 3.4 Sonography -- 3.5 Mammography -- 3.6 MRI -- 3.7 Pregnant and Lactating Women -- 3.8 Conclusion -- References -- 4: Establishing a Program for Young Women at High Risk for Breast Cancer -- 4.1 Defining the "High-Risk Patient": Risk Factors and Risk Categories -- 4.1.1 Non-genetic Risk Factors for Breast Cancer 4.1.1.1 Age -- 4.1.1.2 Environmental and Lifestyle Risk Factors -- 4.1.1.3 Mammographic Breast Density -- 4.1.1.4 Breast Pathology -- 4.1.2 Genetic Risk Factors for Breast Cancer -- 4.1.2.1 Personal History of Breast Cancer -- 4.1.2.2 Family History of Breast Cancer -- 4.1.2.3 Genetic Predisposition -- 4.2 Genetic Counseling and Breast Cancer Risk Assessment Models -- 4.3 Cancer Genetic Risk Assessment -- 4.4 Genetic Test Results -- 4.5 Why Is Genetic Testing Important? -- 4.5.1 Implications for the Affected Individuals -- 4.5.1.1 Implications on the Systemic Therapy Options 4.5.1.2 Implications on the Surgical Interventions -- 4.5.2 Implications for the Unaffected Individuals -- 4.5.3 Implications for the Family Members -- 4.6 How to Establish a Program for Young Women at High Risk for Breast Cancer -- References -- 5: Locoregional Management of Hereditary Breast Cancer -- 5.1 Introduction -- 5.2 Breast Cancer Diagnosis and Testing for BRCA Mutation Status: Clinical Scenarios -- 5.2.1 Diagnosis of a Breast Cancer in a Known Mutation Carrier -- 5.2.2 Detection of a Mutation Carrier Status After Completion of Breast Cancer Treatment
• Publisher Details: Cham, Switzerland : Springer
• Publication Date: 2020
• Extent: 1 online resource
• Subjects: 616.99/449; Breast -- Cancer; Electronic books
• Languages: English
• ISBNs: 9783030247621; 3030247627
• Related ISBNs: 9783030247614
• Notes: Note: Description based on online resource; title from digital title page (viewed on February 28, 2020).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.