The liver : biology and pathobiology /: biology and pathobiology. (2020)

• Record Type: Book
• Further Information: Note: Editors, Irwin M. Arias [and six others].
• Editors: Arias, Irwin M
• Contents: List of Contributors x Preface xx Acknowledgments xxi Part One: Introduction 1 1 Organizational Principles of the Liver 3; Peter Nagy, Snorri S. Thorgeirsson, and Joe W. Grisham 2 Embryonic Development of the Liver 14; Kenneth S. Zaret, Roque Bort, and Stephen A. Duncan Part Two: The Cells 23 Section A: Cell Biology of the Liver 25 3 Cytoskeletal Motors: Structure and Function in Hepatocytes 27; Mukesh Kumar, Arnab Gupta, and Roop Mallik 4 Hepatocyte Surface Polarity 36; Anne Müsch and Irwin M. Arias 5 Primary Cilia 50; Carolyn M. Ott 6 Endocytosis in Liver Function and Pathology 62; Micah B. Schott, Barbara Schroeder, and Mark A. McNiven 7 The Hepatocellular Secretory Pathway 75; Catherine L. Jackson and Mark A. McNiven 8 Mitochondrial Function, Dynamics, and Quality Control 86; Marc Liesa, Ilan Benador, Nathanael Miller, and Orian S. Shirihai 9 Nuclear Pore Complex 94; Michelle A. Veronin and Joseph S. Glavy 10 Protein Maturation and Processing at the Endoplasmic Reticulum 108; Ramanujan S. Hegde 11 Protein Degradation and the Lysosomal System 122; Susmita Kaushik and Ana Maria Cuervo 12 Peroxisome Assembly, Degradation, and Disease 137; Rong Hua and Peter K. Kim 13 Organelle–Organelle Contacts: Origins and Functions 151; Uri Manor 14 Gap and Tight Junctions in Liver: Structure, Function, and Pathology 160; John W. Murray and David C. Spray 15 Ribosome Biogenesis and its Role in Cell Growth and Proliferation in the Liver 174; Katherine I. Farley‐Barnes and Susan J. Baserga 16 miRNAs and Hepatocellular Carcinoma 183; Yusuke Yamamoto, Isaku Kohama, and Takahiro Ochiya 17 Hepatocyte Apoptosis: Mechanisms and Relevance in Liver Diseases 195; Harmeet Malhi and Gregory J. Gores Section B: The Hepatocyte 207 18 Copper Metabolism and the Liver 209; Cynthia Abou Zeid, Ling Yi, and Stephen G. Kaler 19 The Central Role of the Liver in Iron Storage and Regulation of Systemic Iron Homeostasis 215; Tracey A. Rouault, Victor R. Gordeuk, and Gregory J. Anderson 20 Disorders of Bilirubin Metabolism 229; Namita Roy Chowdhury, Yanfeng Li, and Jayanta Roy Chowdhury 21 Hepatic Lipid Droplets in Liver Function and Disease 245; Douglas G. Mashek, Wenqi Cui, Linshan Shang, and Charles P. Najt 22 Lipoprotein Metabolism and Cholesterol Balance 255; Mariana Acuña‐Aravena and David E. Cohen Section C: Transporters, Bile Acids, and Cholestasis 269 23 Bile Acid Metabolism in Health and Disease: An Update 271; Tiangang Li and John Y.L. Chiang 24 TGR5 (GPBAR1) in the Liver 286; Verena Keitel, Christoph G.W. Gertzen, Lina Spomer, Holger Gohlke, and Dieter Häussinger 25 Bile Acids as Signaling Molecules 299; Thierry Claudel and Michael Trauner 26 Hepatic Adenosine Triphosphate‐Binding Cassette Transport Proteins and Their Role in Physiology 313; Peter L.M. Jansen 27 Basolateral Plasma Membrane Organic Anion Transporters 327; M. Sawkat Anwer and Allan W. Wolkoff 28 Hepatic Nuclear Receptors 337; Raymond E. Soccio 29 Molecular Cholestasis 351; Paul Gissen and Richard J. Thompson 30 Pathophysiologic Basis for Alternative Therapies for Cholestasis 364; Claudia D. Fuchs, Emina Halilbasic, and Michael Trauner 31 Adaptive Regulation of Hepatocyte Transporters in Cholestasis 378; James L. Boyer Section D: Non‐Hepatocyte Cells 391 32 Cholangiocyte Biology and Pathobiology 393; Massimiliano Cadamuro, Romina Fiorotto, and Mario Strazzabosco 33 Polycystic Liver Diseases: Genetics, Mechanisms, and Therapies 408; Tatyana Masyuk, Anatoliy Masyuk, and Nicholas LaRusso 34 The Liver Sinusoidal Endothelial Cell: Basic Biology and Pathobiology 422; Karen K. Sørensen and Bård Smedsrød 35 Fenestrations in the Liver Sinusoidal Endothelial Cell 435; Victoria C. Cogger, Nicholas J. Hunt, and David G. Le Couteur 36 Stellate Cells and Fibrosis 444; Youngmin A. Lee and Scott L. Friedman Part Three: Functions of The Liver 455 Section A: Metabolic Functions 457 37 Non‐alcoholic Fatty Liver Disease and Insulin Resistance 459; Max C. Petersen, Varman T. Samuel, Kitt Falk Petersen, and Gerald I. Shulman 38 AMPK: Central Regulator of Glucose and Lipid Metabolism and Target of Type 2 Diabetes Therapeutics 472; Daniel Garcia, Maria M. Mihaylova, and Reuben J. Shaw 39 Insulin‐Mediated PI3K and AKT Signaling 485; Hyokjoon Kwon and Jeffrey E. Pessin 40 Ca2+ Signaling in the Liver 496; Mateus T. Guerra, M. Fatima Leite, and Michael H. Nathanson 41 Clinical Genomics of NAFLD 509; Frank Lammert Section B: Liver Growth and Regeneration 521 42 Stem Cell‐Fueled Maturational Lineages in Hepatic and Pancreatic Organogenesis 523; Wencheng Zhang, Amanda Allen, Eliane Wauthier, Xianwen Yi, Homayoun Hani, Praveen Sethupathy, David Gerber, Vincenzo Cardinale, Guido Carpino, Juan Dominguez‐Bendala, Giacomo Lanzoni, Domenico Alvaro, Eugenio Gaudio, and Lola Reid 43 Developmental Morphogens and Adult Liver Repair 539; Mariana Verdelho Machado and Anna Mae Diehl 44 Liver Repopulation by Cell Transplantation and the Role of Stem Cells in Liver Biology 550; David A. Shafritz and Markus Grompe 45 Liver Regeneration 566; George K. Michalopoulos 46 β‐Catenin Signaling 585; Satdarshan P.S. Monga 47 Polyploidy in Liver Function, Mitochondrial Metabolism, and Cancer 603; Evan R. Delgado, Elizabeth C. Stahl, Nairita Roy, Patrick D. Wilkinson, and Andrew W. Duncan Part Four: Pathobiology of Liver Disease 615 48 Hepatic Encephalopathy 617; Roger F. Butterworth 49 The Kidney in Liver Disease 630; Moshe Levi, Shogo Takahashi, Xiaoxin X. Wang, and Marilyn E. Levi 50 α1‐Antitrypsin Deficiency 645; David A. Rudnick and David H. Perlmutter 51 Pathophysiology of Portal Hypertension 659; Yasuko Iwakiri and Roberto J. Groszmann 52 Non‐alcoholic Fatty Liver Disease: Mechanisms and Treatment 670; Yaron Rotman and Devika Kapuria 53 Alcoholic Liver Disease 682; Bin Gao, Xiaogang Xiang, Lorenzo Leggio, and George F. Koob 54 Drug‐Induced Liver Injury 701; Lily Dara and Neil Kaplowitz 55 Oxidative Stress and Inflammation in the Liver 714; John J. Lemasters and Hartmut Jaeschke 56 The Role of Bile Acid‐Mediated Inflammation in Cholestatic Liver Injury 728; Shi‐Ying Cai, Man Li, and James L. Boyer 57 Toll‐like Receptors in Liver Disease 737; So Yeon Kim and Ekihiro Seki Part Five: Liver Cancer 747 58 Experimental Models of Liver Cancer: Genomic Assessment of Experimental Models 749; Sun Young Yim, Jae‐Jun Shim, Bo Hwa Sohn, and Ju‐Seog Lee 59 Epidemiology of Hepatocellular Carcinoma 758; Hashem B. El‐Serag 60 Mutations and Genomic Alterations in Liver Cancer 773; Jessica Zucman‐Rossi and Jean‐Charles Nault 61 Treatme
• Edition: Sixth edition
• Publisher Details: Chichester : Wiley Blackwell
• Publication Date: 2020
• Extent: 1 online resource
• Subjects: 612.35; Liver -- Physiology; Liver -- Pathophysiology
• Languages: English
• ISBNs: 9781119436836; 9781119436843
• Related ISBNs: 9781119436829
• Notes: Note: Includes bibliographical references and index.; Note: Description based on CIP data; resource not viewed.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
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