Protein homeostasis diseases : mechanisms and novel therapies /: mechanisms and novel therapies. (2020)
- Record Type:
- Book
- Title:
- Protein homeostasis diseases : mechanisms and novel therapies /: mechanisms and novel therapies. (2020)
- Main Title:
- Protein homeostasis diseases : mechanisms and novel therapies
- Further Information:
- Note: Edited by Angel L. Pey.
- Editors:
- Pey, Angel L
- Contents:
- I. Introduction of protein folding and homeostasis 1. Protein folding: how, why, and beyond 2. Protein homeostasis and disease II. Protein folding and homeostasis at the organismal and proteomic scales 3. Caenorhabditis elegans as a model organism for protein homeostasis diseases 4. Proteome-scale studies of protein stability 5. Classifying disease-associated variants using measures of protein activity and stability III. Protein homeostasis disturbance in disease: Genetics, mechanisms, and modulation by natural ligands 6. Protein destabilization and degradation as a mechanism for hereditary disease 7. Detection of amyloid aggregation in living systems 8. Molecular mechanisms of amyloid aggregation in human proteinopathies 9. Metals and amyloid gain-of-toxic mechanisms in neurodegenerative diseases 10. Vitamin B6-dependent enzymes and disease 11. Galactosemia: opportunities for novel therapies 12. Protein homeostasis and regulation of intracellular trafficking of G protein-coupled receptors 13. Structure-guided discovery of pharmacological chaperones targeting protein conformational and misfolding diseases 14. Virtual screening in drug discovery: a precious tool for a still-demanding challenge 15. Differential scanning fluorimetry in the screening and validation of pharmacological chaperones for soluble and membrane proteins 16. Cellular high-throughput screening 17. High-throughput screening for intrinsically disordered proteins by using biophysical methods 18. Natural andI. Introduction of protein folding and homeostasis 1. Protein folding: how, why, and beyond 2. Protein homeostasis and disease II. Protein folding and homeostasis at the organismal and proteomic scales 3. Caenorhabditis elegans as a model organism for protein homeostasis diseases 4. Proteome-scale studies of protein stability 5. Classifying disease-associated variants using measures of protein activity and stability III. Protein homeostasis disturbance in disease: Genetics, mechanisms, and modulation by natural ligands 6. Protein destabilization and degradation as a mechanism for hereditary disease 7. Detection of amyloid aggregation in living systems 8. Molecular mechanisms of amyloid aggregation in human proteinopathies 9. Metals and amyloid gain-of-toxic mechanisms in neurodegenerative diseases 10. Vitamin B6-dependent enzymes and disease 11. Galactosemia: opportunities for novel therapies 12. Protein homeostasis and regulation of intracellular trafficking of G protein-coupled receptors 13. Structure-guided discovery of pharmacological chaperones targeting protein conformational and misfolding diseases 14. Virtual screening in drug discovery: a precious tool for a still-demanding challenge 15. Differential scanning fluorimetry in the screening and validation of pharmacological chaperones for soluble and membrane proteins 16. Cellular high-throughput screening 17. High-throughput screening for intrinsically disordered proteins by using biophysical methods 18. Natural and pharmacological chaperones against accelerated protein degradation: uroporphyrinogen III synthase and congenital erythropoietic porphyria … (more)
- Publisher Details:
- Amsterdam : Academic Press
- Publication Date:
- 2020
- Extent:
- 1 online resource
- Subjects:
- 572.64
Proteins -- Metabolism
Homeostasis
Genetic disorders -- Treatment - Languages:
- English
- ISBNs:
- 9780128191330
- Related ISBNs:
- 9780128191323
- Notes:
- Note: Description based on CIP data; resource not viewed.
- Access Rights:
- Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
- Access Usage:
- Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.
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- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library HMNTS - ELD.DS.492100
- Ingest File:
- 03_054.xml