Retinal pigment epithelium in health and disease. (2020)

• Record Type: Book
• Further Information: Note: Alexa Karina Klettner, Stefan Dithmar, editors.
• Other Names: Klettner, Alexa Karina; Dithmar, S (Stefan)
• Contents: Intro -- Preface -- Contents -- About the Editors -- Part I: Physiological RPE Function -- 1: RPE Histopathology and Morphometry -- Introduction -- Normal Histology -- Cell Morphometry -- Pleomorphism, Polymegathism -- Spatial Distribution, Topography -- Pathology -- Age-Related Changes -- Degenerations -- Biometry-Related Changes -- Age-Related Macular Degeneration -- Retinal Dystrophies -- Proliferative Retinopathies -- Mitochondrial Diseases -- RPE Tumors -- References -- 2: RPE Polarity and Barrier Function -- Introduction The Blood-Retinal Barrier (BRB) Is a Division of the Blood-Brain Barrier (BBB) -- Properties of a Blood-Tissue Barrier -- Epithelial Contributions to the Blood Retinal Barrier (BRB) -- Differentiation vs Maturation In Vivo and in Culture -- What Is an RPE Cell? -- Maturation of RPE Barrier Function in Chick Embryos and Small Mammals -- Maturation of RPE Barrier Function in Humans -- The Structure of Tight Junctions and Pathways for Solutes to Traverse Them -- Protein Composition -- Claudins Are Major Determinants for the Selectivity and Permeability of Tight Junctions Claudins Regulate Additional Pathways of Barrier Function Through Effects on Gene Expression -- Analysis of Paracellular Barrier Function -- Permeation of Polymeric Solutes -- Electrophysiological Assays -- Analysis of RPE Tight Junctions by Multiple Assays -- The Interplay of Tight Junctions and Membrane Transporters -- Retinal Pathology and RPE -- Conclusions -- References -- 3: RPE Phagocytosis -- Introduction -- Experimental Approaches to Quantify the Phagocytic Function of the RPE -- Molecular Mechanisms of RPE Phagocytosis -- Recognition and Binding of POS by RPE Cells Cell Surface Receptors and RPE Signaling Pathways Mediating POS Internalization -- Processing and Degradation of Phagocytosed POS by RPE Cells -- Defects in POS Clearance Phagocytosis by RPE Cells and Human Retinal Disease -- Outlook -- References -- 4: Ion Channels of the Retinal Pigment Epithelium -- Introduction -- Ionic Mechanisms of RPE Function -- Epithelial Transport -- Ion Channels That Contribute to Transepithelial Ion Transport by the RPE -- K+ Buffering in the Subretinal Space -- Ion Channels Contributing to the Control of Subretinal K+ Homeostasis Ca2+-Signaling to Regulate RPE Functions -- Secretion -- Epithelial Transport -- Phagocytosis -- Summary -- References -- 5: RPE and the Vascular Endothelial Growth Factor -- Vascular Endothelial Growth Factor -- RPE Derived VEGF Function in the Healthy Retina -- Development -- Adult Retina -- RPE Derived VEGF in the Diseased Retina -- Regulation of VEGF in the RPE -- Constitutive VEGF -- Hypoxia -- Oxidative Stress and Hyperglycemia -- Inflammation -- Hyperthermia -- Conclusion -- References -- 6: The RPE Cell and the Immune System -- Introduction -- RPE Cell: Role in Ocular Innate Immunity
• Publisher Details: Cham : Springer
• Publication Date: 2020
• Extent: 1 online resource (351 pages)
• Subjects: 617.7/35; Retina -- Pathophysiology; Retina -- Physiology; Epithelium; Epithelium; Retina -- Pathophysiology; Retina -- Physiology; Electronic books
• Languages: English
• ISBNs: 9783030283841; 3030283844
• Related ISBNs: 9783030283834; 3030283836
• Notes: Note: Print version record.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.