Protein allostery in drug discovery. (2019)

• Record Type: Book
• Further Information: Note: Jian Zhang, Ruth Nussinov, editors.
• Editors: Zhang, Jian; Nussinov, Ruth
• Contents: Chapter 1. Allostery in Drug Development.- Chapter 2. Dynamic Protein Allosteric Regulation and Disease.- Chapter 3. Protein Allostery in Rational Drug Design.- Chapter 4. Progress in Allosteric Database.- Chapter 5. Correlation between Allosteric and Orthosteric Sites.- Chapter 6. Characteristics of Allosteric Proteins, Sites and Modulators.- Chapter 7. Advances in the Computational Identification of Allosteric Sites and Pathways in Proteins.- Chapter 8. Advances in NMR Methods to Identify Allosteric Sites and Allosteric Ligands.- Chapter 9. Interrogating Regulatory Mechanisms in Signal-ling Proteins by Allosteric Inhibitors and Activators: A Dynamic View through the Lens of Residue Interaction Network.- Chapter 10. GPCR Allosteric Modulator Discovery.- Chapter 11. Allosteric Small-Molecule Serine/Threonine Kinase Inhibitors.- Chapter 12. Allosteric regulation of protein kinases downstream of PI3-kinase signaling. Chapter 13. Allosteric Modulators of Protein-Protein Interactions (PPIs).- Chapter 14. Allosteric Modulation of Intrinsically Disordered Proteins.- Chapter 15. Engineering Allostery into Proteins.
• Publisher Details: Singapore : Springer
• Publication Date: 2019
• Extent: 1 online resource (xii, 384 pages), illustrations (some color)
• Subjects: 572/.6; Allosteric proteins; Drugs -- Design; Electronic books
• Languages: English
• ISBNs: 9789811387197; 9811387192
• Related ISBNs: 9789811387180; 9811387184
• Notes: Note: Online resource; title from PDF title page (SpringerLink, viewed November 11, 2019).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.