Chimeric antigen receptor T cells : development and production /: development and production. ([2020])

• Record Type: Book
• Further Information: Note: Edited by Kamilla Swiech, Kelen Cristina Ribeiro Malmegrim, Virgínia Picanço-Castro.
• Editors: Swiech, Kamilla; Ribeiro Malmegrim, Kelen Cristina; Picanco-Castro, Virginia
• Contents: 1. CAR-T Cells for Cancer Treatment: Current Design and Next Frontiers Virgínia Picanço-Castro, Kamilla Swiech, Kelen Cristina Ribeiro Malmegrim de Farias, and Dimas Tadeu Covas Part I: Design of Chimeric Antigen Receptors and Vector Production 2. Selection of Antibody Fragments for CAR-T Cell Therapy from Phage Display Libraries Nestor F. Leyton-Vastro, Marcelo M. Brigido, and Andrea Q. Maranhão 3. Phase I/II Manufacture of Lentiviral Vectors under GMP in an Academic Setting Anindya Dasgupta, Stuart Tinch, Kathleen Szczur, Rebecca Ernst, Nathaniel Shryock, Courtney Kaylor, Kendall Lewis, Eric Day, Timmy Truong, and William Swaney 4. Production of Lentivirus for the Establishment of CAR-T Cells Marlous G. Lana and Bryan E. Strauss 5. Optimized Production of Lentiviral Vectors for CAR-T Cell Pablo Diego Moço, Mário Soares de Abreu Neto, Daianne Maciely Carvalho Fantacini, and Virgínia Picanço-Castro 6. Lentiviral Vectors Production in Suspension Culture Using Serum-Free Medium for the Transduction of CAR-T Cells Aline Do Minh, Michelle Yen Tran, and Amine A. Kamen Part II: CAR-T Cells Generation and Manufacturing 7. In vitro Transcribed (IVT)-mRNA CAR Therapy Development Miliotou N. Androulla and Papadopoulou C. Lefkothea 8. Generation of Chimeric Antigen Receptor T Cells Using Gammaretroviral Vectors Feiyan Mo and Maksim Mamonkin 9. Generation of CAR+ T Lymphocytes using the Sleeping Beauty Transposon System Leonardo Chicaybam, Luiza Abdo, and Martín H. Bonamino 10. Platforms for Clinical-grade Car-T Cell Expansion Amanda Mizukami and Kamilla Swiech 11. CAR-T Cell Expansion in a Xuri Cell Expansion System W25 Trevor A. Smith 12. Methods and Process Optimization for Large Scale CAR T Expansion Using the G-Rex Cell Culture Platform Josh Ludwig and Mark Hirschel Part III: CAR-T Cells Characterization and Quality Control 13. Replication Competent Lentivirus Analysis of Vector Transduced T Cell Products used in Cancer Immunotherapy Clinical Trials Kenneth Cornetta, Sue Koop, Emily Nance, Kimberley House, and Lisa Duffy 14. Immunophenotypic Analysis of CAR-T Cells Júlia Teixeira Cottas de Azevedo, Amanda Mizukami, Pablo Diego Moço and Kelen Cristina Ribeiro Malmegrim 15. Approaches of T Cell Activation and Differentiation for CAR-T Cell Therapies Robert D. Schwab, Darel Martínez Bedoya, Tiffany R. King, Bruce L. Levine, and Avery D. Posey, Jr. 16. Determination of Cytotoxic Potential of CAR-T Cells in Co-cultivation Assays Renata Silvestre Nacasaki, Pablo Diego Moço, and Virgínia Picanço-Castro 17. Analysis of CAR-mediated Tonic Signaling Hugo Calderon, Maksim Mamonkin, and Sonia Guedan 18. Generation of Tumor Cells Expressing Firefly Luciferase (fLuc) to Evaluate the Effectiveness of CAR in a Murine Model Marcelo de Souza Fernandes Pereira, Daianne Maciely Carvalho Fantacini, and Virginia Picanço e Castro 19. Analysis of Antitumor Effects of CAR-T Cells in Mice with Solid Tumors Alba Rodriguez-Garcia, Keisuke Watanabe, and Sonia Guedan.
• Publisher Details: New York : Humana Press
• Publication Date: 2020
• Copyright Date: 2020
• Extent: 1 online resource, illustrations (chiefly color)
• Subjects: 616.07/97; T cells -- Receptors; Antigens; Cancer -- Immunological aspects; Electronic books
• Languages: English
• ISBNs: 9781071601464; 1071601466
• Related ISBNs: 9781071601457
• Notes: Note: Online resource; title from PDF title page (SpringerLink, viewed November 14, 2019).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.