Proteomic and metabolomic approaches to biomarker discovery. (2019)

• Record Type: Book
• Further Information: Note: Edited by Haleem J. Issaq, Timothy D. Veenstra.
• Editors: Issaq, Haleem J; Veenstra, Timothy Daniel, 1966-
• Contents: 1. Biomarker discovery: Study design and execution; 2. Proteomic and mass spectrometry technologies for biomarker discovery; 3. Tissue sample preparation for proteomic analysis; 4. Sample preparation in global metabolomics of biological fluids and tissues; 5. Serum and plasma collection: Preanalytical variables and standard operating procedures in biomarker research; 6. Sample depletion, fractionation, and enrichment for biomarker discovery; 7. Current NMR strategies for biomarker; 8. Gas chromatography/mass spectrometrybased metabonomics; 9. Liquid chromatographic methods combined with mass spectrometry in metabolomics; 10. Capillary electrophoresis-mass spectrometry for proteomic and metabolic; 11. Associating 2-DE and CPLLs for low-abundance protein discovery: A winning strategy; 12. Two-dimensional difference in gel electrophoresis for biomarker discovery; 13. Affinity-targeting schemes for protein biomarkers; 14. Protein and metabolite identification; 15. Quantitative proteomics in development of disease protein biomarkers; 16. Mass spectrometry and NMR spectroscopy based quantitative metabolomics; 17. Top-down mass spectrometry for protein molecular diagnostics, structure analysis, and biomarker discovery; 18. Using data-independent mass spectrometry to extend detectable dynamic range without prior fractionation; 19. Imaging mass spectrometry of intact biomolecules in tissue section; 20. Mass spectrometry-based approach for protein biomarker verification; 21. Mass spectrometry metabolomic data handling for biomarker discovery; 22. Analytical methods and biomarker validation; 23. Multivariate analysis for metabolomics and proteomics data; 24. Cell surface protein enrichment for biomarker and drug target discovery using mass spectrometry-based proteomic; 25. Advances in lipidomics for cancer biomarker discovery; 26. Mass spectrometry for the identification of protein biomarkers in urinary extracellular vesicles; 27. Designing clinical studies for biomarker discovery: The DESIGN criteria
• Edition: Second edition
• Publisher Details: Amsterdam : Academic Press
• Publication Date: 2019
• Extent: 1 online resource
• Subjects: 610.28; Biochemical markers; Proteomics -- Methodology; Metabolism -- Regulation
• Languages: English
• ISBNs: 9780128197882
• Related ISBNs: 9780128186077
• Notes: Note: Description based on CIP data; resource not viewed.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.