Clinical molecular medicine : principles and practice /: principles and practice. (2019)

• Record Type: Book
• Further Information: Note: Edited by Dhavendra Kumar.
• Editors: Kumar, Dhavendra
• Contents: Section I Fundamentals of Molecular and Cell Biology 1. Genes, genome and chromosomes 2. Cellular structure and molecular systems 3. RNA, Transcription factors and Ribosome 4. Proteins and Proteomics 5. Mitochondria and oxidative phosphorylation 6. Reproductive and developmental molecular biology 7. Genomic variation, molecular basis of evolution, comparative molecular biology 8. Bioinformatics and systems biology Section II Molecular basis of human disease 9. Molecular basis of growth disorders: Primordial growth disorders; Overgrowth and asymmetric growth disorders 10. Developmental disorders: major molecular groups and malformations: transcriptionopathies, spliceopathies, ciliopathies, RASopathies, nuclear envelopathies and many others 11. Disorders of sexual differentiation: Mullerian and anti-Mullerian hormones and steroids/ androgens 12. Disorders of cardiovascular development and circulation: TBX molecular system, notch signaling pathway, sarcomere proteins, vascular endothelial growth factors and transforming growth factors 13. Disorders of lipids: familial hypercholesterolemia, complex hyperlipidemia and other rare disorders 14. Disorders of glycemic metabolism and regulation: Diabetes mellitus & Obesity- Mendelian and complex disorders 15. Disorders of brain development: microcephaly, holoprosencephaly, lissencephaly and neuronal migration disorders 16. Lysosomal and other storage disorders of the nervous system: Tay Sachs; Mucopolysaccharidoses; Gaucher’s disease; Fabry’s disease; Glycogen storage diseases and other rare examples 17. Molecular basis of childhood autism, learning / intellectual difficulties and attention deficit hyperactivity disorder 18. Disorders of ion-channels: Epilepsy and Cardiac arrhythmias 19. Disorders of eye development, ocular structure and function; cataracts, choroidoretinal disorders and glaucoma 20. Disorders of cranio-facial development: fibroblasts, fibroblast growth factors and fibroblast growth factor receptors 21. Molecular basis of hearing loss: connexins and auditory neuro-receptors 22. Disorders of bone and joints: abnormal collagen- structure and function; calcium and vitamin D regulation and homeostasis 23. Disorders of voluntary (skeletal muscle): Dystrophin, Sacroglycans and other molecular structures in muscle function 24. Disorders of skin and appendages: Keratin and other dermal molecular structures 25. Disorders of immune function: T-cell, immunoglobins and tissue-host response 26. Disorders of abnormal hemoglobin structure and function: sickle cell disease, beta thalassemia, alpha thalassemia, hemochromatosis and abnormal iron storage 27. Disorders of blood groups: ABO incompatibility, Rhesus iso-sensitization and rare blood groups 28. Disorders of coagulation and bleeding: abnormal platelet structure and function; Hemophilia and van Will brand disease: Rare clotting disorders 29. Molecular basis of respiratory disorders: bronchial asthma, pulmonary failure and high altitude living 30. Disorders of digestion and nutrition including molecular basis of inflammatory bowel disease 31. Molecular basis of inflammatory disorders (cytokines, and interferon): Rheumatoid arthritis, systemic lupus erythmematosis and other disorders 32. Molecular basis of Infectious diseases: human immunodeficiency virus (HIV), Tuberculosis, Malaria, Influenza, Oncogenic viruses, Parasites, Microbial response- susceptibility and protection, Anti-microbials and Vaccines 33. Molecular basis of neoplasia: oncogenes, tumor suppressor genes, DNA repair and hematologic malignancies (leukemias and lymphomas) 34. Molecular basis of neuro-degenerative disorders: Huntington’s disease, Spino-cerebellar ataxias, Motor Neuron Disease, Multiple sclerosis and others 35. Molecular basis of renal and urinary structural and functional disorders 36. Molecular basis of neuro-psychiatric disorders: Depression, Bi-polar disorder, Schizophrenia, Alzheimer’s and other dementia disorders (Taupathies, abnormal proteins in amyloid plaques and neurofibrillary tangles) 37. Molecular basis of ageing and apoptosis: Premature aging-progenies Section III Molecular therapeutics 38. Genomics and molecular biology applications for new drug design and development 39. Molecular basis of adverse drug reactions and favorable drug response 40. Targeted molecular therapy 41. Gene and Cell therapy including anti-sense oligonucleotide therapy 42. Stem cell and regenerative medicine 43. RNA-Interference therapy 44. Pharmacogenetics/pharmacogenomics and Personalized Medicine 45. Stratified and Precision Medicine including Nanomedicine
• Publisher Details: Amsterdam : Academic Press
• Publication Date: 2019
• Extent: 1 online resource
• Subjects: 572.8; Molecular biology; Cytology; Medical sciences
• Languages: English
• ISBNs: 9780128094426
• Related ISBNs: 9780128093566
• Notes: Note: Description based on CIP data; resource not viewed.
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