Computer modelling for nutritionists. ([2019])

• Record Type: Book
• Further Information: Note: Mark Tomás Mc Auley.
• Authors: Mc Auley, Mark Tomás
• Contents: Intro; Preface; Acknowledgements; Contents; About the Author; 1 Introduction; 1.1 Introduction: The Systems Biology Paradigm Shift; 1.2 What Is Computational Modelling?; 1.3 Why Nutrition Needs Modelling; 1.4 Computer Models and Nutrition Research; 1.4.1 Folate Metabolism; 1.4.2 Models of Folate Metabolism; 1.4.3 Cholesterol Metabolism; 1.4.4 Models of Cholesterol Metabolism; 1.5 Can Modelling Unravel the Relationship Between Diet and Healthspan?; 1.6 Exercises; References; 2 Kinetics; 2.1 What Is Kinetics?; 2.2 Deterministic Kinetics and the Law of Mass Action; 2.3 Zero Order Reactions 2.4 First Order Reactions2.5 Second Order Rate Laws; 2.6 Exercises; References; 3 Enzyme Kinetics; 3.1 Introduction; 3.1.1 Michaelis-Menten Kinetics; 3.1.2 Michaelis Menten (Reversible); 3.2 Enzyme Inhibition; 3.3 The Hill Equation; 3.4 Exercises; References; 4 Model Building: Part One; 4.1 The Steps in Building a Kinetic Model; 4.2 Step One: Identifying a System to Model and Defining a Hypothesis; 4.3 Step Two: Listing the Variables and How They Interact; 4.4 Step Three: Creating a Network Diagram; 4.5 Step Four: Identifying and Using a Software Tool 4.6 Step Five: Adding Biochemical Reactions4.6.1 Adding a Rate Law Which Does Not Exist in COPASI/CellDesigner; 4.7 Exercises; References; 5 Model Building: Part Two; 5.1 Introduction; 5.2 Step Six: Model Parameterization; 5.3 Step Seven: Model Simulation; 5.4 Step Eight: Validation and Hypothesis Exploration; 5.5 Step Ten: Model Archiving; 5.6 Exercises; References; 6 Model Analysis in Greater Depth; 6.1 Steady State Analysis; 6.2 Phase Space Analysis; 6.3 Parameter Perturbations and Bifurcations; 6.4 The Brusselator and Limit Cycles; 6.5 Identifying the Stability of Larger Models 6.5.1 Identifying Model Stability Using COPASI6.6 Performing a Local Parameter Scan; 6.7 Metabolic Control Analysis; 6.8 Performing a Sensitivity Analysis; 6.9 Exercises; References; 7 Investigating Cholesterol Metabolism and Its Intersection with Ageing; 7.1 Cholesterol Metabolism: Some Mechanistic Detail; 7.2 Cholesterol Absorption and Ageing; 7.3 Hepatic LDLr and Ageing; 7.4 Cholesterol Biosynthesis; 7.5 Exercises; References; 8 Modelling Folate Metabolism and DNA Methylation; 8.1 Introduction; 8.2 Explore Folate Metabolism and Health; 8.3 Computationally Modelling DNA Methylation 8.4 Stochastic Modelling DNA Methylation8.5 Rationale for Modelling DNA Methylation Using a Stochastic Framework; 8.6 Exercises; References; Index
• Publisher Details: Cham : Springer
• Publication Date: 2019
• Copyright Date: 2019
• Extent: 1 online resource
• Subjects: 572/.4072; Nutrition -- Computer simulation; Nutrition -- Mathematical models; Electronic books; Electronic books
• Languages: English
• ISBNs: 9783319399942; 3319399942
• Related ISBNs: 9783319399928
• Notes: Note: Includes bibliographical references and index.; Note: Online resource; title from PDF title page (SpringerLink, viewed October 16, 2019).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.