Advances in membrane proteins building, signaling and malfunction /: building, signaling and malfunction. (2019)

• Record Type: Book
• Further Information: Note: Yu Cao, editor.
• Other Names: Cao, Yu
• Contents: Intro; Acknowledgement; Contents; Lipid Homeostasis on Cell Membrane; Phospholipid Biosynthesis (Kennedy Pathway); Biosynthesis of Phosphatidic Acid (PA); Biosynthesis of PIs; Biosynthesis of PS; Biosynthesis of PE; Biosynthesis of PC; Phospholipid Remodeling (Non-Kennedy Pathway); LPCAT1; LPCAT2; LPCAT3; LPCAT4; LPEAT1; LPEAT2; Phospholipids and Membrane; PA/LPA and Membrane; PIs and Membrane; PS and Membrane; PE and Membrane; PCs and Membrane; SM; SPT and Its Subunits; SMS Family; SM as a Critical Component of Lipid Rafts; SM-Enriched Cell Membrane Lipid Rafts Early Structural Work on RhodopsinGPCR Structural Biology After 2007; GPCR Dynamics; References; Membrane Proteins as Targets for Biological Drugs; Introduction; Targeting Membrane Expressed Receptors; Antibody Drug Conjugates; PK and In Vivo Activity of Biologics; Advances in Immuno-oncology; Concluding Remarks; References; Cell Adhesion Molecules; Brief Introduction; IgSF; Structure; Function; Wiring of Brain Synapses; Integrins; Activation; Function; Selectins; Functions; Cadherins; Functions; References; The Biosynthesis and Folding of Oily Peptide Chains; Introduction; ER Targeting Translocation and ER TargetingFunctions of the Signal Peptides and Anchor Sequences; Protein Folding in the ER; Chaperone Assisted Folding; The BiP Chaperone Complex; The Lectin-Chaperones Complex; Co-translational Folding; Co-translational Event Involving the Ribosome; Translocon as a Hub for Co-translational Folding; Protein Modification in the ER; Glycosylation in the ER; Disulfide Bond Formation; Peptidyl-Prolyl cis-trans Isomerization; Protein Assembly in the ER; Selective Oligomerization; Hetero-oligomerization of Membrane Proteins; Homo-oligomerization; Proteins Exit from the ER Golgi ProcessingDefective Biosynthesis of Membrane Proteins and Human Diseases; Human Diseases Caused by Defects in Protein Biosynthesis; Rescue Defective Function by Pharmacological Chaperones; References; Mechanism of Quality Control of Nascent Membrane Proteins; Maturation of Membrane Proteins Within ER Membrane; Membrane Protein Folding Is Coupled with Biosynthesis, Translocation, Modification, and Topogenesis; Overview of Protein Folding, Protein Degradation, and Ubiquitin-Proteasome System (UPS); Protein Degradation from ER: ER-Associated Degradation (ERAD) Pathway
• Publisher Details: Singapore : Springer
• Publication Date: 2019
• Extent: 1 online resource (132 p.)
• Subjects: 572/.696; Membrane proteins; Electronic books
• Languages: English
• ISBNs: 9789811390777; 9811390770
• Related ISBNs: 9811390762; 9789811390760
• Notes: Note: Online resource; title from PDF title page (EBSCO, viewed October 11, 2019).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.