Multifaceted roles of crystallography in modern drug discovery. (2015)

• Record Type: Book
• Further Information: Note: Edited by Giovanna Scapin, Disha Patel, Eddy Arnold.
• Editors: Scapin, Giovanna; Patel, Disha; Arnold, Eddy
• Other Names: NATO Advanced Study Institute on Crystallography in Drug Discovery: a Tool Against CBRN Agents
• Contents: Preface -- List of Contributors -- Engineering G Protein-Coupled Receptors for Drug Design -- Structural Insights into Activation and Allosteric Modulation of G Protein-Coupled Receptors -- Epigenetic Drug Discovery -- Crystallography and Biopharmaceuticals -- Structural Chemistry and Molecular Modeling in the Design of DPP4 Inhibitors -- Considerations for Structure-Based Drug Design Targeting HIV-1 Reverse Transcriptase.-Protein-Ligand Interactions as the Basis for Drug Action -- The Protein Data Bank: Overview and Tools for Drug Discovery -- Small Molecule Crystal Structures in Drug Discovery -- Protein Aggregation and its Prediction -- Importance of Protonation States for the Binding of Ligands to Pharmaceutical Targets -- Protein-Protein Interactions: Structures and Druggability -- Achieving High Quality Ligand Chemistry in Protein-Ligand Crystal Structures for Drug Design -- Molecular Obesity, Potency and Other Addictions in Drug Discovery -- Adventures in Small Molecule Fragment Screening by X-ray Crystallography for Drug Discovery -- Structure-Based Drug Design to Perturb Function of a tRNA-Modifying Enzyme by Active Site and Protein-Protein Interface Inhibition -- Molecular Interaction Analysis for Discovery of Drugs Targeting Enzymes and for Resolving Biological Function.
• Publisher Details: Dordrecht, The Netherlands : Springer
• Publication Date: 2015
• Extent: 1 online resource (xi, 240 pages), illustrations (some color)
• Subjects: 615.1/9; Pharmaceutical chemistry -- Congresses; Drugs -- Design -- Congresses; Drug development -- Congresses; Crystallography -- Congresses; Structural bioinformatics -- Congresses; Chemistry, Pharmaceutical; Crystallography; Drug development; Drugs -- Design; Pharmaceutical chemistry; Structural bioinformatics; Congress; Electronic books; Conference papers and proceedings
• Languages: English
• ISBNs: 9789401797191; 9401797196; 9401797188; 9789401797184
• Related ISBNs: 9789401797184; 9789401797245
• Notes: Note: Online resource; title from PDF title page (SpringerLink, viewed March 5, 2015).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.