Bioactive Ceramides in Health and Disease : Intertwined Roles of Enigmatic Lipids /: Intertwined Roles of Enigmatic Lipids. (2019)

• Record Type: Book
• Further Information: Note: Johnny Stiban, editor.
• Other Names: Stiban, Johnny
• Contents: Intro; Preface; Contents; About the Editor; 1: Introduction: Enigmas of Sphingolipids; References; 2: Prokaryotic and Mitochondrial Lipids: A Survey of Evolutionary Origins; 2.1 Introduction; 2.2 Bacterial and Mitochondrial Membranes; 2.3 Bacterial Lipids; 2.3.1 Environmental Factors; 2.3.1.1 Pressure; 2.3.1.2 Temperature; 2.3.1.3 Hypersalinity; 2.3.1.4 pH; 2.3.2 The Gram-Negative Outer Membrane; 2.3.3 Common, and Uncommon, Lipids in Bacteria; 2.3.3.1 Hopanoids and Sterols; 2.3.3.2 Sphingolipids and Lipid Rafts; 2.3.3.3 Ladderanes; 2.4 Lipids in Mitochondria 2.4.1 Mitochondrial Cholesterol and Other Sterols2.4.2 Mitochondrial Sphingolipids; 2.5 Programmed Cell Death; 2.5.1 Mitochondria and Apoptosis; 2.5.2 Bacterial Apoptosis; 2.6 Conclusions and Future Directions; References; 3: Ceramide Channels; 3.1 Introduction; 3.1.1 Membrane Channels; 3.1.2 Membrane Channels Formed by Cellular Lipids; 3.2 Evidence for the Existence of Ceramide Channels; 3.2.1 Ceramide-Induced Permeabilization of the Mitochondrial Outer Membrane to Proteins; 3.2.2 Ceramide Addition Permeabilizes Phospholipid Membranes; 3.2.3 Model of the Ceramide Channel 3.2.4 Visualization of the Ceramide Channel by Electron Microscopy3.2.5 Dynamics of Ceramide Channels; 3.2.6 Ceramide Channel Destabilization by Anti-apoptotic Bcl-2 Family Proteins; 3.2.7 Synergy Between Ceramide and the Pro-apoptotic Protein Bax; 3.2.8 Membrane Specificity of Ceramide Channel Formation; 3.3 Conclusions; References; 4: A Stroll Down the CerS Lane; 4.1 A Stroll Through the CerS Sequence, from N- to C-Terminus; 4.1.1 The CerS N-Terminus Faces the ER Lumen and Contains a Glycosylation Site; 4.1.2 The First TMD Targets CerS to the ER 4.1.3 A Conserved, Enigmatic Homeobox-Like Domain4.1.4 The TLC Domain Contains the Active Site and Determines Substrate Specificity; 4.1.4.1 The Lag1p Motif May Contain the N-Acylation Site; 4.1.4.2 Long Chain Base Specificity; 4.1.4.3 Acyl-CoA Specificity Is Determined by the Last Loop of the TLC Domain; 4.1.4.4 CerS2 Contains a S1P Receptor-Like Motif; 4.1.5 The CerS C-Terminus Faces the Cytosol and Contains Phosphorylation Sites; 4.2 CerS Regulation; 4.2.1 CerS Dimerization; 4.2.2 CerS Inhibition; 4.2.3 Transcriptional Regulation of CerS; 4.3 Summary and Conclusions; References 5: The Role of Ceramide 1-Phosphate in Inflammation, Cellular Proliferation, and Wound Healing5.1 Introduction; 5.1.1 Ceramide 1-Phosphate; 5.1.2 The Biosynthesis of Ceramide 1-Phosphate in Mammalian Cells; 5.2 The Generation of Eicosanoids and Induction of the Inflammatory Response by Ceramide 1-Phosphate; 5.3 Ceramide 1-Phosphate and Cell Survival; 5.3.1 The Role of Ceramide 1-Phosphate in Cellular Proliferation; 5.3.2 Acid Sphingomyelinase; 5.3.3 The Association of Ceramide 1-Phosphate with the PI3-K/AKT, NF-kB, and Other Survival Pathways
• Publisher Details: Cham : Springer
• Publication Date: 2019
• Extent: 1 online resource (159 pages)
• Subjects: 572/.57; Ceramides; Bioactive compounds; Bioactive compounds; Ceramides; Electronic books
• Languages: English
• ISBNs: 9783030211622; 3030211622
• Related ISBNs: 9783030211615
• Notes: Note: Print version record.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.