Bile acids and their receptors. (2019)

• Record Type: Book
• Further Information: Note: Stefano Fiorucci, Eleonora Distrutti, editors.
• Other Names: Fiorucci, Stefano; Distrutti, Eleonora
• Contents: Intro; Preface; Contents; The Pharmacology of Bile Acids and Their Receptors; 1 Introduction; 2 Bile Acids, a Family of Unconventional Steroids; 3 Bile Acids Before the Discovery of Their Receptors; 4 The Discovery of the Bile Acid-Activated Receptors: FXR and Other Nuclear Receptors; 4.1 FXR, the Bile Acid Sensor in Drug Discovery: 1999-2019; 5 Secondary Bile Acids and GPBAR1; 6 Conclusions; References; Bile Acid-Activated Receptors: GPBAR1 (TGR5) and Other G Protein-Coupled Receptors; 1 Introduction; 2 TGR5 and S1PR2 Signaling Pathways; 3 Tissue Distribution of TGR5 and S1PR2 4 Role of S1PR2 Signaling in Hepatocytes5 Role of S1PR2 and TGR5 in Liver Sinusoidal Endothelial Cells (LSECs); 6 Role of S1PR2 and TGR5 in Hepatic Stellate Cells (HSCs) and Hepatic Myofibroblasts (hMFs); 7 Role of S1PR2 and TGR5 in Macrophages; 8 Role of S1PR2 and TGR5 in Biliary Epithelial Cells; 9 Loss of S1PR2 and TGR5 in Mice and Humans: Contribution to Liver Disease?; 10 S1PR2 and TGR5 in Cholestatic and Biliary Diseases: Pathogenetic Role and Potential Therapeutic Target?; 11 S1PR2 and TGR5 Metabolic Liver Diseases: Potential Therapeutic Target? 12 Role in Advanced Liver Disease: Potential Therapeutic Target?13 Summary and Perspectives; References; Bile Acid-Activated Receptors: A Review on FXR and Other Nuclear Receptors; 1 Introduction; 2 Bile Acid-Activated Receptor Farnesoid X Receptor (FXR, NR1H4); 2.1 FXR and Bile Acid Metabolism; 2.2 FXR and Lipid Metabolism; 2.3 FXR and Glucose Metabolism; 2.4 FXR as a Therapeutic Target; 3 Bile Acids and Small Heterodimer Partner (SHP, NR0B2); 3.1 SHP and Bile Acid Metabolism; 3.2 SHP and Lipid Metabolism; 3.3 SHP and Glucose Metabolism 4 Bile Acid-Activated Receptor Pregnane X Receptor (PXR, NR1I2)4.1 PXR and Bile Acid Metabolism; 4.2 PXR and Lipid Metabolism; 4.3 PXR and Glucose Metabolism; 5 Bile Acids and Constitutive Androstane Receptor (CAR, NR1I3); 5.1 CAR and Bile Acid Metabolism; 5.2 CAR and Lipid Metabolism; 5.3 CAR and Glucose Metabolism; 6 Bile Acid-Activated Receptor Vitamin D Receptor (VDR, NR1l1); 7 Conclusions and Perspectives; References; The Enterokine Fibroblast Growth Factor 15/19 in Bile Acid Metabolism; 1 FGF Family; 2 Endocrine FGFs; 3 FGF15/FGF19 in Energy Homeostasis 4 Role of FGF15/FGF19 in the Gut-Liver Axis5 FGF19 and Hepatic Diseases; 6 FGF19-Based Therapy: Promising Reality; References; Signaling from Intestine to the Host: How Bile Acids Regulate Intestinal and Liver Immunity; 1 Bile Acids and Intestinal Microbiota; 2 Bile Acids and Immune System; 2.1 Role of Bile Acids in the Regulation of Intestinal and Liver Immunity; 2.2 Immune-Regulatory Effects of Bile Acids in Myeloid Cells: Monocytes/Macrophages and Dendritic Cells; 2.3 Immune-Regulatory Effects of Bile Acids in Lymphoid Cells; References
• Publisher Details: Cham : Springer
• Publication Date: 2019
• Extent: 1 online resource (374 pages)
• Subjects: 612.35; Bile acids; Bile acids; Electronic books
• Languages: English
• ISBNs: 9783030220051; 3030220052
• Notes: Note: Includes bibliographical references.; Note: Online resource; title from PDF title page (SpringerLink, viewed September 20, 2019).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.