Principles of Bone Biology. (2019)

• Record Type: Book
• Further Information: Note: John P. Bilezikian, T. John Martin, Thomas L. Clemens, Clifford Rosen.
• Editors: Bilezikian, John P; Martin, T. John; Clemens, Thomas L; Rosen, Clifford
• Contents: PART I Basic Principles A. Cell Biology 1. Endochondral and Intramembraneous Bone Development; 2. Mesenchymal Stromal Cells; 3. Hematopoietic-Bone Cell Interactions; 4. Osteoblasts; 5. Osteoclasts; 6. Osteocytes; 7. Transcriptional Control of Osteoblast Differentiation; 8. Wnt Signaling and Bone Cell Activity; 9. Vascular and Nerve Interactions; 10. Coupling of Bone Formation and Resorption; 11. Bone Remodeling; 12. Aging and Bone B. Biochemistry 13. Type I Collagen Structure, Synthesis, and Regulation; 14. Collagen Cross-Linking and Metabolism; 15. Noncollagenous Bone Matrix Proteins (including osteopontin); 16. Bone Proteinases; 17. Integrins and Other Cell Surface Attachment Molecules of Bone Cells; 18. Intercellular Junctions and Cell–Cell Communication in the Skeletal System C. Bone Remodeling and Mineral Homeostasis 19. Histomorphometric Analysis of Bone Remodeling; 20. Phosphorus Homeostasis and Related Disorders; 21. Magnesium Homeostasis; 22. Metals in Bone: Aluminum, Boron, Cadmium, Chromium, Lanthanum, Lead, Silicon, and Strontium; 23. Biology of the Extracellular Ca2+-Sensing Receptor D. Endocrine and Paracrine Regulation of Bone 24. Parathyroid Hormone: Molecular Biology; 25. Paracrine PTHrP in Bone: Physiology and Pharmacology; 26. Actions of Parathyroid Hormone on the Vasculature and Cardiovascular System and Vascular, Cardiovascular, and Neurological Actions of Parathyroid-Related Protein; 27. PTH and PTHrP Actions on Kidney; 28. Receptors for Parathyroid Hormone (PTH) and PTH-Related Protein; 29. 1α, 25(OH)2 Vitamin D3Vitamin D Nuclear Receptor (VDR) and Plasma Vitamin D-Binding Protein (DBP) Structures and Ligand Shape Preferences for Genomic and Rapid Biological Responses; 30. Vitamin D Gene Regulation; 31. Noncalcemic Actions of Vitamin D; 32. Cellular Actions of Parathyroid Hormone; 33. Calcitonin peptides; 34. Regulation of Bone Remodeling by Central and Peripheral Nervous System E. Other Systemic Hormones that Influence Bone Metabolism 35. Estrogens and Progestins; 36. Physiological Actions of Parathyroid Hormone (PTH) and PTH-Related Protein: Epidermal, Mammary, Reproductive, Pancreatic Tissues; 37. The Pharmacology of Selective Estrogen Receptor Modulators; 38. Thyroid Hormone and Bone; 39. Clinical and Basic Aspects of Glucocorticoid Action in Bone 40. Effects of Diabetes and Insulin on Bone Physiology; 41. Androgens Receptor Expression and Steroid Action in Bone F. Local Regulators 42. Insulin-like Growth Factors and the IGF Binding Proteins: Implications for Bone Biology; 43. Platelet-Derived Growth Factor and the Skeleton; 44. Notch Signaling and its Ligands; 45. Fibroblast Growth Factor (FGF) and FGF Receptor Families in Bone; 46. Vascular Endothelial Growth Factor and Osteogenic-Angiogenic Coupling; 47. Transforming Growth Factor-β; 48. Bone Morphogenetic Proteins and the Skeleton and Bone Morphogenetic Protein Receptors and Actions; 49. Non-Skeletal Actions of RANK Ligand; 50. Local Regulators of Bone: IL-1, TNF, Lymphotoxin, Interferon-γ, the LIF/IL-6 Family, and Additional Cytokines; 51. Prostaglandins and Bone Metabolism PART II Molecular Mechanisms of Metabolic Bone Disease 52. Molecular Actions of PTH1R and their implications; 53. Multiple Endocrine Neoplasia Type 1; 54. Parathyroid Hormone-Related Peptide and Other Systemic Factors in Skeletal Manifestations of Malignancy; 55. Localized Osteolysis; 56. Genetic Regulation of Parathyroid Gland Development; 57. Genetic Disorders Caused by PTH/PTHrP Receptor Mutations; 58. Molecular Basis of PTH Overexpression; 59. Diseases Resulting from Defects in the G Protein Gsα; 60. Renal Osteodystrophy: Pathogenic Mechanisms and Therapeutic Options; 61. Osteogenesis Imperfecta; 62. Hereditary Deficiencies in Vitamin D Action; 63. FGF 23; 64. Tumor-Induced Osteomalacia; 65. Osteopetrosis; 66. Hypophosphatasia: Nature's Window on Alkaline Phosphatase Function in Humans; 67. Paget's Disease of Bone; 68. Genetic Determinants of Bone Mass and Osteoporotic Fracture / Genomic Approaches in Skeletal Research PART III Pharmacological Mechanisms of Therapeutics 69. Pharmacological Mechanisms of Therapeutics: Parathyroid Hormone; 70. Calcium; 71. Drugs Acting on the Calcium Receptor: Calcimimetics and Calcilytics; 72. Bisphosphonates: Mechanisms of Action; 73. Pharmacologic basis of RANK L inhibition; 74. Pharmacologic basis of Sclerostin Inhibition; 75. Vitamin D and Analogues; 76. Mechanisms of Exercise PART IV Methods in Bone Research 77. Application of Genetically Modified Animals in Bone Research; 78. Biochemical Markers of Bone Metabolism; 79. Microimaging; 80. Macroimaging; 81. Methods in Lineage Tracing; 82. Histomorphometry in Rodents; 83. Bone Strength Testing in Rodents; 84. Endocrinology of Bone
• Edition: 4th
• Publisher Details: Academic Press
• Publication Date: 2019
• Extent: 1 online resource (2024 pages)
• Languages: English
• ISBNs: 9780128148426
• Related ISBNs: 012814842X
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.