Neuroblastoma : clinical and surgical management /: clinical and surgical management. ([2020])

• Record Type: Book
• Further Information: Note: Sabine Sarnacki, Luca Pio, editors.
• Editors: Sarnacki, Sabine; Pio, Luca
• Contents: Intro; Foreword; Contents; Part I: Epidemiology, Biology and Pathology Assessment; 1: Epidemiology; 1.1 Descriptive Epidemiology; 1.1.1 Incidence and Epidemiological Features; 1.1.2 Survival; 1.2 Etiology; 1.2.1 Perinatal Characteristics; 1.2.1.1 Gestational Age, Birth Weight, and Size for Gestational Age; 1.2.2 Maternal Vitamin or Folic Acid Intake Around Pregnancy; 1.2.3 Breastfeeding; 1.2.4 Congenital Malformations; 1.2.5 Parental Smoking and Alcohol Consumption; 1.2.6 Pesticides Exposures; 1.2.7 Other Factors; References; 2: Biology of Neuroblastoma; 2.1 Introduction 2.2 Hereditary Genetic Factors2.2.1 Somatic Genetic Alterations; 2.2.1.1 Copy-Number Alterations; 2.2.1.2 Single-Gene Mutations; 2.2.1.3 Expression Profiles; 2.2.1.4 Spatial and Temporal Heterogeneity; References; 3: Neuroblastoma Pathogenesis; 3.1 Neuroblastoma, a Disease of the Neural Crest; 3.2 Key Genes Involved in Neuroblastoma Pathogenesis; 3.2.1 PHOX2B, a Transcription Factor Involved in Syndromic and Familial Neuroblastoma Cases; 3.2.2 MYCN, a Transcription Factor Associated with High-Risk Neuroblastoma 3.2.3 Implication of the ALK Tyrosine Kinase Receptor in Sporadic, Familial, and Syndromic Cases of Neuroblastoma3.2.4 Telomere Dysfunction Linked to TERT and ATRX Genomic Aberrations; 3.2.5 LIN28B; 3.3 Noncoding RNAs in Neuroblastoma Pathogenesis; 3.4 Metastasis Study in Neuroblastoma Models; 3.4.1 Orthotopic Xenografts in the Mouse; 3.4.2 LMO1; 3.4.3 SEMA3C; 3.5 Cell Identity and Plasticity in Neuroblastoma; References; 4: Neuroblastoma Pathology; 4.1 Introduction; 4.2 Historical Considerations; 4.3 Pathology Diagnosis; 4.3.1 Tumor Sampling/Handling 4.3.2 Differential Diagnosis4.4 International Neuroblastoma Pathology Classification (INPC); 4.4.1 Histological Categories and Subtypes; 4.4.2 Prognostic Grouping (Favorable Histology vs. Unfavorable Histology); 4.4.3 Age Factor in Neuroblastoma; 4.5 Bone Marrow Involvement in Neuroblastoma; 4.5.1 Sample Collection for Testing; 4.5.2 Trephine Biopsies; 4.5.3 Immunocytology (IC); 4.5.4 Quantitative Reverse Transcription Polymerase Chain Reaction (qRT-PCR); 4.6 Tumor Progression in Neuroblastoma; 4.7 New Directions of Neuroblastoma Pathology Research 4.7.1 Potential "Actionable/Druggable" Targets in Neuroblastoma4.7.2 Molecular Targeting Therapies for Unfavorable Histology Neuroblastoma Resistant to the Current Therapy; 4.8 Conclusions; References; Part II: Imaging; 5: Radiology; 5.1 Introduction; 5.2 Imaging Modalities: Technical Aspects and Rational for Use; 5.2.1 Plain Films; 5.2.2 Ultrasonography; 5.2.3 Computed Tomography; 5.2.4 Magnetic Resonance Imaging; 5.2.5 Nuclear Medicine; 5.2.6 DICOM Data Storage; 5.3 Diagnostic Imaging at Diagnosis; 5.3.1 Classical Imaging Patterns; 5.3.2 Specific Diagnostic Issues
• Publisher Details: Cham, Switzerland : Springer
• Publication Date: 2020
• Extent: 1 online resource (375 pages)
• Subjects: 616.99383; Neuroblastoma -- Treatment; Electronic books
• Languages: English
• ISBNs: 9783030183967; 3030183963
• Notes: Note: Includes bibliographical references.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.