Understanding Atrial Fibrillation. (2019)

• Record Type: Book
• Further Information: Note: Peter Spector.
• Authors: Spector, Peter
• Contents: Acknowledgements: 5 Preface 6 Why do we need another book about atrial fibrillation? 6 What type of problem is fibrillation? 6 Structure of the book 8 Part I: Building Blocks of Fibrillation 9 Excitation and Propagation 9 Source Sink Relationships 9 What Determines Source Sink Balance? 10 Propagation and Reentry 10 Requirements for Reentry 10 What Makes a Circuit? 11 Source Sink Balance and Rotors 11 Wave length 12 Wave Length, Path Length and Reentry 13 Restitution 13 Initiating Reentry 14 Part II: AF Mechanisms 17 The Evolution of Current Concepts 17 Focal or Disseminated? 18 Multiwavelet Reentry Moves to the Forefront 19 The Mass Hypothesis of Atrial Fibrillation 22 James Cox: Leveraging the Mass Hypothesis 23 Principles of Propagation: Implications for Fibrillation 24 Multi-Wavelet Reentry: The Probabilistic Formulation 25 Collision Probability 25 Episode Duration and Collision Probability 25 Quantifying the Propensity to Perpetuate Multi-wavelet Reentry 26 Predicting the Impact of Ablation 28 Focal Rotors: 34 Micro-Reentry 38 Fibrillatory Conduction or Multi-Wavelet Reentry? 42 Is fibrillatory Conduction Active or Passive? 42 Dynamics of Structural Micro-Reentry in the Presence of Multi-Wavelet Reentry 45 Impact of a Structural Reentrant Circuit on the Average Duration of Multi-Wavelet Reentry 46 Location of AF Drivers 47 Which Driver Type and Where? 48 Why are Fast Sites Fast ? 48 Impact of Regional Heterogeneity on the Dynamics of AF Drivers 48 Tissue Properties and Spatial Stability 48 Cores in the Setting of Interactions with Other Waves 49 Variable Meander Distance and Rotor Distribution 50 Where are Driver Sites? 50 Principles of Propagation: Driver Interactions in Fibrillation 51 Waves and Wave-Sources 51 Where Waves Collide 51 Source-Source Interaction: Who Influences Whom? 52 Part III: Working with Incomplete Information 54 Cardiac Mapping 54 Sampling and Interpolation 54 The Image Processing Analogy for Cardiac Mapping 55 Sample Density and Sequential Mapping 56 Currents Sources and Potential Fields 56 Who Cares about Spatial Resolution? 58 Fractionation Results from Inadequate Spatial Resolution 58 Dominant Frequency Mapping 59 What determines Spatial Resolution? 60 Electrode Design and Spatial Resolution 60 Sample Density and Atrial Fibrillation 63 Multi-site Simultaneous Mapping 64 Sequential Mapping of Atrial Fibrillation 64 Improving the Sensitivity of Tissue Property Mapping 70 But What Kind of Driver is it? 71 What Should we Do with the Patient That Comes to the Lab Tomorrow ? 72 What About When Pulmonary Vein Isolation Isn’t Enough? 73 Putting it All Together: AF in Three Questions 75 Appendix I: Calculating Probability in a Random Walk 77 Appendix II: Dominant Frequency Analysis 78 Appendix III: A Stupid Idea, but a Learning Opportunity 79 References 81
• Edition: 1st
• Publisher Details: Wiley-Blackwell
• Publication Date: 2019
• Extent: 1 online resource (184 pages)
• Languages: English
• ISBNs: 9781119524625
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.