Centenarians An Example of Positive Biology /: An Example of Positive Biology. (2019)

• Record Type: Book
• Further Information: Note: Calogero Caruso, editor.
• Other Names: Caruso, Calogero
• Contents: Intro; Preface; Contents; 1: Chance and Causality in Ageing and Longevity; 1.1 Introduction; 1.2 Role of Chance in Ageing and Longevity; 1.3 Socio-economic Development and Life Expectancy: Causal Role of Education; 1.4 Role of Sex and Gender in Ageing and Longevity; 1.5 Inflamm-ageing and Oxidative Stress as Causal Factors of Ageing; 1.6 The (De)regulation of Nutrient-Sensing Pathways in Ageing and Longevity; 1.7 Physical Activity and Longevity; 1.8 Psychological Stress and Longevity; 1.9 Conclusion; References; 2: Phenotypic Aspects of Longevity; 2.1 Introduction 2.2 Haematochemical Values2.3 Age-Related Diseases in Centenarians; 2.4 Oxidative Stress and Inflammation; 2.5 Psychological and Cognitive Function; 2.6 Body Composition; 2.7 Conclusion; References; 3: Centenarian Offspring as a Model of Successful Ageing; 3.1 Introduction; 3.2 Hereditary and Modifiable Factors Influencing Longevity in Centenarian Offspring; 3.3 Phenotypic Features of Centenarian Offspring; 3.4 Age-Related Disease Risk Profile in Centenarian Offspring; 3.4.1 Inflammatory Status; 3.4.2 CVD Risk Profile 3.5 Other Biomarkers of Successful Ageing in Centenarian Offspring3.6 Immunophenotype of Centenarian Offspring and Successful Immunosenescence; 3.7 Conclusion; References; 4: Individual Longevity Versus Population Longevity; 4.1 Introduction; 4.2 Individual Longevity; 4.3 The Validation of Age; 4.4 Some Examples of (In)validation of the Age of Alleged Supercentenarians (Extracted from [8]); 4.5 About the Age of the Oldest Person on Earth; 4.6 Population Longevity; 4.7 The Blue Zones; 4.8 Conclusion; References; 5: Dietary Inflammatory Index in Ageing and Longevity 5.1 Introduction5.2 The Dietary Inflammatory Index; 5.3 DII and Metabolic Disorders; 5.4 DII and Cardiovascular Diseases; 5.5 DII and Cancer; 5.6 DII and Longevity; 5.7 Conclusion; References; 6: Genetic Signatures of Centenarians; 6.1 Exceptional Longevity Is an Inherited Phenotype; 6.2 Case-Control Candidate Gene Approach; 6.3 Case-Control Studies Without A Priori Hypothesis (Non-hypothesis Driven); 6.4 Meta-Analysis of GWAS; 6.5 Whole Exome Sequencing (WES) and Whole Genome Sequencing (WGS); 6.6 Conclusion; References; 7: Epigenetics and Ageing; 7.1 DNA Methylation 7.2 Histone Modifications7.3 Non-coding RNAs; 7.4 Epigenetic Modifications in Ageing; 7.4.1 DNA Methylation and Ageing; 7.4.2 Histone Modifications and Ageing; 7.4.3 miRNAs and Ageing; 7.5 Epigenetic Modifications in Age-Related Diseases; References; 8: Lifestyle Choices, Psychological Stress and Their Impact on Ageing: The Role of Telomeres; 8.1 Introduction; 8.2 Associations Between Lifestyle Choices and Telomere Length Biology; 8.2.1 Physical Activity; 8.2.2 Diet; 8.2.2.1 Food Compounds; 8.2.2.2 Mediterranean Diet; 8.2.3 Psychological Stress; 8.2.3.1 Phobic Anxiety
• Publisher Details: Cham : Springer
• Publication Date: 2019
• Extent: 1 online resource (182 p.)
• Subjects: 618.97; Centenarians -- Health and hygiene; Centenarians -- Medical care; Electronic books; Electronic books
• Languages: English
• ISBNs: 9783030207625; 3030207625
• Related ISBNs: 9783030207618; 3030207617
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.