Polymyxin antibiotics : from laboratory bench to bedside /: from laboratory bench to bedside. ([2019])

• Record Type: Book
• Further Information: Note: Jian Li, Roger L. Nation, Keith S. Kaye, editors.
• Editors: (Pharmacologist), Li, Jian; Nation, Roger L; Kaye, Keith S
• Contents: Overview.- Multidrug resistant Gram-negative pathogens: the urgent need for 'old' polymyxins.- Discovery, antibacterial spectrum and chemistry.- Mechanisms of antibacterial activity.- Mechanisms of resistance.- Bioanalysis and stability of polymyxins.- In vitro pharmacodynamics and PK/PD in animals.- Antibacterial susceptibility breakpoints.- Labeling of parenteral products of colistin methanesulfonate.- Meta-analysis of polymyxin use in patients.- Clinical use of colistin.- Clinical use of polymyxin B.- Pharmacokinetics, pharmacodynamics, toxicodynamics and dosing recommendations.- Rational combinations with other antibiotics.- Toxicities in patients: management and mechanisms.- Antiendotoxin effect.- Discovery of novel polymyxin-like antibiotics.- Conclusion.
• Publisher Details: Cham : Springer
• Publication Date: 2019
• Copyright Date: 2019
• Extent: 1 online resource, illustrations (some color)
• Subjects: 615.7/922; Polymyxin; Antibiotics; Electronic books
• Languages: English
• ISBNs: 9783030163730; 3030163733
• Related ISBNs: 9783030163716
• Notes: Note: Includes bibliographical references and index.; Note: Online resource; title from PDF title page (SpringerLink, viewed August 28, 2019).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.