Evaluating Evidence of Mechanisms in Medicine : Principles and Procedures /: Principles and Procedures. (2018)

• Record Type: Book
• Further Information: Note: Veli-Pekka Parkkinen, Christian Wallmann, Michael Wilde, Brendan Clarke, Phyllis Illari, Michael P Kelly, Charles Norell, Federica Russo, Beth Shaw, Jon Williamson.
• Authors: Parkkinen, Veli-Pekka; Wallmann, Christian; Wilde, Michael; Clarke, Brendan; Illari, Phyllis; Kelly, Michael P; Norell, Charles; Russo, Federica; Shaw, Beth; Williamson, Jon
• Contents: 1 Introduction1.1 What is a mechanism?1.2 Where does evidence of a mechanism come from?1.3 Why consider evidence of mechanisms?1.3.1 Evaluating efficacy1.3.2 Evaluating external validity1.3.3 Other questions1.3.4 Importance of considering evidence of mechanisms2 How to consider evidence of mechanisms: a summary2.1 Questions to address2.2 Quality level of evidence and status of claim2.3 Identifying evidence of mechanisms in the literature2.4 Evaluating evidence of mechanisms2.5 Using evidence of mechanisms to evaluate causal claims2.6 Overall approach3 Identifying evidence of mechanisms in the literature3.1 Hypothesize a mechanism3.2 Search the literature3.3 Identify the evidence most relevant to the mechanism hypothesis3.4 Presenting the evidence of mechanisms4 Evaluating evidence of mechanisms4.1 Considerations for evaluating evidence of mechanism4.2 Presenting quality of evidence of mechanisms5 Using evidence of mechanisms to evaluate efficacy and external validity5.1 Efficacy5.2 External validity6 Glossary7 References8 Acknowledgements9 Appendix A. A critical appraisal tool for evidence of mechanisms10 Appendix B. GRADE tables with mechanism assessment11 Appendix C: Databases for evidence of mechanisms12 Appendix D: Assessing exposures12.1 Example: carcinogenicity of benzo[a]pyrene12.2 Comparison to IARC12.3 Molecular epidemiology12.4 Comparison to SYRINA.
• Publisher Details: Cham : Springer
• Publication Date: 2018
• Copyright Date: 2018
• Extent: 1 online resource (125 pages)
• Subjects: Philosophy; Genetic epistemology; Philosophy -- Epistemology; Philosophy: epistemology & theory of knowledge; Medical -- Ethics; Philosophy; Medicine-Philosophy
• Languages: English
• ISBNs: 9783319946108
• Related ISBNs: 9783319946092
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.