A systems biology approach to advancing adverse outcome pathways for risk assessment. (2018)

• Record Type: Book
• Further Information: Note: Natàlia Garcia-Reyero, Cheryl A. Murphy, editors.
• Editors: Garcia-Reyero, Natàlia; Murphy, Cheryl A
• Contents: 1. Introduction -- Part I: Biology -- 2. "Non-model" species for eco and human health risk assessment -- 3. The fish embryo as a model for eco-toxicology and other potential models -- 4. Invertebrates/Plants -- 5. Behavioral/Neurobehavioral linkages to AOPs -- 6. Species extrapolation -- common pathways etc -- 7. Life History Evolution, incorporating evolutionary processes into AOPs to extrapolate -- Part II: Incorporating Biology into AOPs -- 8. Use of HTS assays to infer MIEs -- 9. AOP development: how to infer and define KER -- 10. The development of quantitative AOPs -- Part IV: Incorporating Modeling into AOPs.-11.Computational approaches (network science, etc) in AOPs: linking molecular datasets -- 12.Computational approaches : Dynamic Energy Budgets -- 13. Modeling approaches in AOPs: extrapolation from individual to population -- 14. Modeling approaches that augment AOPs: GUTS, QSAR, TKTD PBTKTD -- 15. Exposure science and other stressors? How to incorporate -- 16. AOP as an organizing framework and implications for biological science-AOP evolution -- 17. Use and acceptance of AOPs for regulatory applications, use of AOPs in human risk assessment, and legislation.
• Publisher Details: Cham, Switzerland : Springer
• Publication Date: 2018
• Extent: 1 online resource
• Subjects: 615.7/040724; Toxicity testing; Systems biology; MEDICAL -- Pharmacology; Systems biology; Toxicity testing; Pharmacology/Toxicology; Electronic books
• Languages: English
• ISBNs: 9783319660844; 3319660845
• Related ISBNs: 9783319660820; 3319660829
• Notes: Note: Online resource; title from PDF title page (SpringerLink, viewed March 1, 2018).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.