Carbonic Anhydrase As Drug Target : Thermodynamics and Structure of Inhibitor Binding /: Thermodynamics and Structure of Inhibitor Binding. ([2019])

• Record Type: Book
• Further Information: Note: Daumantas Matulis, editor.
• Editors: Matulis, Daumantas
• Contents: Final ToC tbd. 1) Description of human carbonic anhydrases (12 catalytically active human isoforms; isoforms as drug targets, enzymatic activity, catalytic mechanism, thermodynamics of protonation of the water molecule in the active site) -- 2) Thermal stabilities of all isoform CA catalytic domains -- Thermodynamics of inhibitor binding to CAs (incl. intrinsic thermodynamics -- not mentioned important subject in most CA literature) -- 3) Comparison of methods to determine inhibitor binding to CAs (ITC, FTSA, enzymatic activity assays) -- 4) Chemical synthesis of CA inhibitors -- 5) X-ray crystallographic structures of CAs and their complexes with inhibitors -- 6) Antibodies against CAs.
• Publisher Details: Cham, Switzerland : Springer
• Publication Date: 2019
• Extent: 1 online resource (358 pages)
• Subjects: 572/.7; 611.01816; Carbonic anhydrase; Drug targeting; Carbonic anhydrase; Drug targeting; Electronic books; Electronic books
• Languages: English
• ISBNs: 9783030127800
• Related ISBNs: 303012780X; 9783030127787
• Notes: Note: Description based on online resource; title from digital title page (viewed on July 11, 2019).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.