Intracellular signalling proteins. (2019)

• Record Type: Book
• Further Information: Note: Rossen Donev.
• Authors: Donev, Rossen
• Contents: Front Cover; Intracellular Signalling Proteins; Copyright; Contents; Contributors; Chapter One: Voices from the dead: The complex vocabulary and intricate grammar of dead cells; 1. Introduction; 2. The language of cell death; 3. An expanded view of the role of cell death in homeostasis; 4. A universally heard language; 4.1. Phagocytic clearance and anti-inflammation; 4.2. Extended homeostatic effects; 4.3. Hierarchical considerations; 5. Paradigm; 6. A complex language; 6.1. Variables associated with the dead or dying cell; 6.1.1. Mode of cell death 6.1.2. Suicidal stimuli initiating apoptosis6.1.3. Elapsed time from apoptotic initiation; 6.1.4. Lineage of the apoptotic cell; 6.2. Variables associated with the responding cell; 6.2.1. Lineage of the responding cell; 6.2.2. Organ of residence of the responding cell; 6.2.3. State of activation of the responding cell; 6.2.4. Stage of maturation or differentiation of the responding cell; 6.2.5. Concentration-dependent responses to diffusible factors released by apoptotic cells; 6.2.6. Neoplastic versus non-neoplastic responding cells 6.2.7. Age of the organism in which the responding cell resides6.3. Variables associated with transmission of the message; 6.3.1. Diffusible mediators; 6.3.1.1. Sources of increased information capacity associated with diffusible mediators; 6.3.1.2. Sources of increased noise associated with diffusible mediators; 6.3.2. Receptor-ligand interactions; 6.3.3. Additional mechanisms of message transmission; 7. Inbuit mechanisms that improve the signal-to-noise ratio; 8. An intricate grammar; 9. Conclusions; References Chapter Two: Nucleobindins and encoded peptides: From cell signaling to physiology1. Introduction; 2. Structural characteristics of the NUCB protein family; 3. Biochemical and structural properties of NUCB; 4. Structure of the EF-hand pair in NUCB1; 5. Calcium induces conformational changes in NUCB1; 6. DNA binding property of NUCB1; 7. Post-translational modification; 8. Subcellular distribution; 9. NUCB protein-protein interactions that mediate different physiological functions; 9.1. NUCB1/COXs and NUCB2/ART-1: Functions in inflammation response
• Publisher Details: Cambridge, MA : Academic Press, an imprint of Elsevier
• Publication Date: 2019
• Extent: 1 online resource
• Subjects: 571.74; Cellular signal transduction; Proteins; Protein-protein interactions; SCIENCE / Life Sciences / Anatomy & Physiology; Electronic books; Electronic books
• Languages: English
• ISBNs: 9780128155622; 0128155620
• Related ISBNs: 9780128155615
• Notes: Note: Includes bibliographical references.; Note: Online resource; title from PDF title page (EBSCO, viewed April 30, 2019).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.