Chronic Lymphocytic Leukemia. ([2019])

• Record Type: Book
• Further Information: Note: Michael Hallek, Barbara Eichhorst, Daniel Catovsky, editors.
• Editors: Hallek, Michael; Eichhorst, Barbara; Catovsky, Daniel
• Contents: Intro; Contents; Part I: Pathophysiology; 1: Chronic Lymphocytic Leukemia: Who, How, and Where?; 1.1 Introduction; 1.2 Who; 1.2.1 Genetic Predisposition to CLL; 1.2.2 Monoclonal B-Cell Lymphocytosis; 1.2.3 Cell of Origin; 1.3 How; 1.3.1 Mechanisms of Leukemogenesis; 1.3.2 Genetic Defects; 1.3.3 B-Cell Receptor; 1.4 Where; 1.4.1 Microenvironmental Stimuli; 1.4.2 Cellular Components; 1.5 Conclusions; References; Part II: Diagnostics; 2: Laboratory Diagnosis of Chronic Lymphocytic Leukaemia; 2.1 Introduction; 2.2 Full/Complete Blood Count; 2.3 Morphology; 2.4 Immunophenotype 2.5 CLL Diagnostic Algorithms Based on Immunophenotype 2.5.1 CLL Scoring Systems; 2.5.2 ERIC/ESCCA Approach to Improving Diagnostic Reproducibility; 2.6 Molecular Diagnostics; 2.6.1 Chromosomal Deletions and Aneuploidy; 2.6.2 Chromosomal Translocations; 2.6.3 The Immunoglobulin Gene; 2.6.4 Other Molecular Abnormalities; 2.7 Differential Diagnosis; 2.7.1 Mantle Cell Lymphoma; 2.7.2 B-Prolymphocytic Leukaemia; 2.7.3 Waldenström's Macroglobulinemia/Lymphoplasmacytic Lymphoma; 2.7.4 Cold Agglutinin Disease (CAD); 2.7.5 Monoclonal B-Cell Lymphocytosis 2.8 Richter's Syndrome/Large Cell Transformation 2.9 Summary; References; Part III: Clinical Presentation; 3: The Clinical Presentation of CLL; 3.1 Introduction; 3.2 Demographics; 3.2.1 Incidence; 3.2.2 Age Distribution; 3.2.3 Gender; 3.3 Clinical Features; 3.3.1 Presentation; 3.3.2 Lymphoid Involvement; 3.3.3 Extramedullary Features; 3.3.4 Constitutional Symptoms; 3.3.5 Second Malignancies; 3.4 Laboratory Investigations; 3.4.1 Full Blood Count; 3.4.2 Other Blood Tests; 3.4.3 Bone Marrow (BM) Examination; 3.4.4 Imaging Tests; 3.4.5 Cytogenetics/Molecular Investigations 4.3.9.1 Recurrent Acquired Single Nucleotide Variants (SNV) in CLLNOTCH1; SF3B1; 4.3.9.2 Hierarchical Model Integrating Prognostic Information from Genomic Studies; 4.3.9.3 Predicting the Risk of High-Grade Transformation; 4.4 Prognostic Markers in the Era of Novel Therapies; 4.5 Outlook; References; Part V: Treatment; 5: Guidelines for Diagnosis, Indications for Treatment, Response Assessment, and Supportive Management of Chronic Lymphocytic Leukemia: The 2018 Update; 5.1 Introduction
• Publisher Details: Cham, Switzerland : Springer
• Publication Date: 2019
• Extent: 1 online resource (171 pages)
• Subjects: 616.99/419; Chronic lymphocytic leukemia; Leukemia, Lymphocytic, Chronic, B-Cell; Electronic books; Electronic books
• Languages: English
• ISBNs: 9783030113926; 3030113922
• Related ISBNs: 9783030113919
• Notes: Note: Description based on online resource; title from digital title page (viewed on May 22, 2019).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.