Experimental Cholestasis Research. (2019)

• Record Type: Book
• Further Information: Note: Mathieu Vinken.
• Editors: Vinken, Mathieu
• Contents: 1. Mechanisms of Drug-Induced Cholestasis Eva Gijbels and Mathieu Vinken 2. LC-MS/MS Analysis of Bile Acids in In Vitro Samples Debbie Dewaele, Pieter Annaert, and Eef Hoeben 3. Pipe-3D: A Pipeline Based on Immunofluorescence, 3D Confocal Imaging, Reconstructions, and Morphometry for Biliary Network Analysis in Cholestasis Amruta Damle-Vartak, Brigitte Begher-Tibbe, Georgia Gunther, Fabian Geisler, Nachiket Vartak, and Jan G. Hengstler 4. Vesicle-Based and Hepatocyte-Based Assays for Identification of Drug Candidates Inhibiting BSEP Function Pieter Van Brantegem, Neel Deferm, Bing Qi, Tom De Vocht, and Pieter Annaert 5. The C-DILI™ Assay: An Integrated In Vitro Approach to Predict Cholestatic Hepatotoxicity Jonathan P. Jackson and Kenneth R. Brouwer 6. In Vivo Measurement of Hepatic Drug Transporter Inhibition with Radiolabeled Bile Acids Stef De Lombaerde, Sara Neyt, Christian Vanhove, and Filip De Vos 7. Measuring the Impact of Bile Acids on the Membrane Order of Primary Hepatocytes and Isolated Mitochondria by Fluorescence Imaging and Spectroscopy Tânia Sousa, Rui E. Castro, Ana Coutinho, Cecília M.P. Rodrigues, Manuel Prieto, and Fábio Fernandes 8. The Role and Study of Mitochondrial Impairment and Oxidative Stress in Cholestasis Reza Heidari and Hossein Niknahad 9. Measuring Apoptosis and Necrosis in Cholestatic Liver Injury Benjamin L. Woolbright and Hartmut Jaeschke 10. Necrosome Formation and Necroptosis in Experimental Cholestasis Marta Bento Afonso and Cecília Maria Pereira Rodrigues 11. Proteomics in Primary Biliary Cholangitis You Li, Ruqui Tang, Patrick S.C. Leung, Eric Gershwin, and Xiong Ma 12. Transcriptomics Analysis of Cholestatic Compounds In Vitro Céline Parmentier, Philippe Couttet, Marianne Uteng, Armin Wolf, and Lysiane Richert 13. Systems Microscopy of Stress Response Pathways in Cholestasis Research Johannes P. Schimming, Bas ter Braak, Marije Niemeijer, Steven Wink, and Bob van de Water 14. Mouse Models for Diseases in the Cholangiocyte Lineage Noémi Van Hul, Urban Lendahl, and Emma R. Andersson 15. Common Bile Duct Ligation as Model for Secondary Biliary Cirrhosis Sanne Van Campenhout, Hans Van Vlierberghe, and Lindsey Devisscher 16. 3, 5-Diethoxycarbonyl-1, 4-Dihydrocollidine Diet: A Rodent Model in Cholestasis Research Elisa Pose, Pau Sancho-Bru, and Mar Coll 17. A Rotavirus-Induced Mouse Model to Study Biliary Atresia and Neonatal Cholestasis Sujit K. Mohanty, Bryan Donnelly, Haley Temple, and Gregory M. Tiao 18. Zebrafish as a Model to Study Cholestatic Liver Diseases Duc-Hung Pham and Chunyue Yin 19. Set-Up and Use of HepaRG Cells in Cholestasis Research Christiane Guguen-Guillouzo and André Guillouzo 20. Organotypic 3D HepaRG Liver Model for Assessment of Drug-Induced Cholestasis Sreenivasa C. Ramaiahgari and Stephen S. Ferguson 21. Establishment of Sandwich Cultures of Primary Human Hepatocytes Eva Gijbels, Tamara Vanhaecke, and Mathieu Vinken 22. Detection of Drug-Induced Cholestasis Potential in Sandwich-Cultured Human Hepatocytes Neel Deferm, Lysiane Richert, Pieter Van Brantegem, Tom De Vocht, Bing Qi, Peter de Witte, Thomas Bouillon, and Pieter Annaert 23. Ex Vivo Model in Cholestasis Research Ruby E.H. Karsten, Dorenda Oosterhuis, Louise A. van Wijk, and Peter Olinga 24. Patient-Derived Organoids from Human Bile: An In Vitro Method to Study Cholangiopathies Carol J. Soroka, David N. Assis, and James L. Boyer 25. Use of Biliary Organoids in Cholestasis Research Fotios Sampaziotis, Olivia Tysoe, Teresa Brevini, and Ludovic Vallier 26. In Silico Approaches to Predict Drug-Transporter Interaction Profiles: Data Mining, Model Generation, and Link to Cholestasis Sankalp Jain and Gerhard F. Ecker.
• Publisher Details: New York : Humana Press
• Publication Date: 2019
• Copyright Date: 2019
• Extent: 1 online resource (399 pages)
• Subjects: Medicine; Toxicology; Clinical medicine; Medical -- Gastroenterology; Hepatology; Medical -- Pharmacology; Pharmacology
• Languages: English
• ISBNs: 9781493994205
• Related ISBNs: 9781493994199
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.