Thymus transcriptome and cell biology. (2019)

• Record Type: Book
• Further Information: Note: Geraldo A. Passos, editor.
• Editors: Passos, Geraldo A
• Contents: 1. History of the thymus: From a vestigial organ to the programming of immunological self-tolerance.- 2. Thymus Ontogeny and Development.- 3. The Ins and Outs of Thymic Epithelial Cell Differentiation and Function.- 4. T-Cell Development: From T-Lineage Specification to Intrathymic Maturation.- 5. Intrathymic cell migration: implications in thymocyte development and T-cell repertoire formation.- 6. Thymic crosstalk: an overview of the complex cellular interactions that control the establishment of T-cell tolerance.- 7. The Autoimmune Regulator (AIRE) gene, the master activator of self-antigen expression in the thymus.- 8. Aire Mutations and Autoimmune Diseases.- 9. The thymus as a mirror of the body's gene expression.- 10. Functional genomics of the infant human thymus: Aire and minipuberty.- 11. Thymus transcriptome of TGF-β superfamily.- 12. Development of thymic regulatory T lymphocytes.- 13. Adding insult to injury: improving the regenerative capacity of the aged thymus following clinically induced damage.- 14. Thymus rejuvenation after autologous hematopoietic stem cell transplantation in patients with autoimmune diseases.
• Publisher Details: Cham, Switzerland : Springer
• Publication Date: 2019
• Extent: 1 online resource (xvii, 318 pages), illustrations (some color)
• Subjects: 571.9/66; T cells; Electronic books
• Languages: English
• ISBNs: 9783030120405; 3030120406
• Related ISBNs: 9783030120399
• Notes: Note: Online resource; title from PDF title page (SpringerLink, viewed April 24, 2019).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.