Gastrointestinal stromal tumor : research and practice /: research and practice. (2019)

• Record Type: Book
• Further Information: Note: Editors: Yukinori Kurokawa and Yoshito Komatsu.
• Editors: Kurokawa, Yukinori; Komatsu, Yoshito
• Contents: Intro; Foreword; Preface; Contents; 1: Epidemiology; 1.1 Reported Incidence of GIST and Challenge in Its Ascertainment; 1.1.1 Challenges in Determining the Incidence; 1.1.2 Dataset Used in This Chapter; 1.1.3 Age and Sex of Patients; 1.2 Site of Tumor and Stage Distribution; 1.3 Treatment Modalities; 1.4 Molecular/Genomic Frequencies; 1.5 Survival and Predictors of Recurrence; 1.6 Summary; References; 2: Histology; 2.1 The Definition of GIST; 2.2 Histopathological Features of GIST; 2.3 Extragastrointestinal Stromal Tumor; 2.4 Phenotype-Genotype Correlation in GIST 2.5 SDH-Deficient GIST2.6 Familial GIST; 2.7 Neurofibromatosis Type 1-Related GIST; 2.8 Quadruple Wild-Type GIST; 2.9 Tips for Histopathological Risk Assessment of GIST; 2.10 TKI Treatment-Related Histological Changes in GIST; 2.11 Differential Diagnosis of GIST; 2.11.1 Leiomyoma; 2.11.2 Leiomyosarcoma; 2.11.3 Schwannoma; 2.11.4 Inflammatory Myofibroblastic Tumor; 2.11.5 Desmoid-Type Fibromatosis; 2.11.6 Other Miscellaneous Tumors; References; 3: Genetics; 3.1 Introduction; 3.2 Overview of the Genes Associated with GIST; 3.2.1 c-KIT Gene; 3.2.2 PDGFRA Gene; 3.2.3 NF-1 Gene 3.2.4 SDH Gene Family3.3 Characteristics of GIST by Genotype; 3.3.1 Characteristics of GIST with a c-KIT Mutation; 3.3.2 GIST with PDGFRA Mutations; 3.3.3 GIST with NF1 Mutations; 3.3.4 GIST with SDH Mutations; 3.4 Familial GIST and Its Clinical Features; 3.5 The Relation Between Mutations and Molecular Target Therapy with Imatinib; 3.6 Molecular Mechanisms of Resistance to Imatinib; 3.7 Liquid Biopsy in Gastrointestinal Stromal Tumors; 3.8 Conclusion; References; 4: Diagnostic Imaging of Gastrointestinal Stromal Tumor; 4.1 Introduction; 4.2 Staging 4.2.1 Staging of Gastric GIST4.2.2 Staging of Small Intestinal GIST; 4.3 Primary Tumor; 4.3.1 CT; 4.3.2 MRI; 4.3.3 Positron Emission Tomography/Computed Tomography (PET/CT); 4.4 Metastases; 4.5 Monitoring Tumor Response; 4.6 Conclusion; References; 5: Risk Classification; 5.1 Introduction; 5.2 Risk-Stratification Systems; 5.2.1 National Institutes of Health (NIH) Consensus Criteria; 5.2.2 Armed Forces Institute of Pathology (AFIP) Criteria; 5.2.3 Modified NIH Criteria (Joensuu Risk Criteria); 5.2.4 Contour Maps; 5.2.5 Prognostic Nomograms 5.2.6 C-kit and PDGFRA Gene Mutations5.2.7 Other Pathological Variables and Molecular Markers; 5.3 Discussion; References; 6: Treatment Guidelines; 6.1 Introduction; 6.2 Very Small GISTs (<2 cm); 6.3 Localized Resectable GISTs (Initially Resectable); 6.4 Locally Advanced GISTs (Initially Unresectable); 6.5 Unresectable or Metastatic GISTs; 6.5.1 Initial Approach for Unresectable or Metastatic GISTs; 6.5.2 Second-Line Treatment for Unresectable or Metastatic GISTs; 6.5.3 Third-Line Treatment for Unresectable or Metastatic GISTs; 6.5.4 Other Optional Treatments; References
• Publisher Details: Singapore : Springer
• Publication Date: 2019
• Extent: 1 online resource
• Subjects: 616.99/433; Gastrointestinal system -- Cancer; Gastrointestinal system -- Tumors; Gastrointestinal system -- Research; HEALTH & FITNESS / Diseases / General; MEDICAL / Clinical Medicine; MEDICAL / Diseases; MEDICAL / Evidence-Based Medicine; MEDICAL / Internal Medicine; Gastrointestinal system -- Cancer; Gastrointestinal system -- Tumors; Surgical Oncology; Gastroenterology; Electronic books; Electronic books
• Languages: English
• ISBNs: 9789811332067; 9811332061; 9789811332074
• Related ISBNs: 9789811332050; 9811332053; 981133207X
• Notes: Note: Includes bibliographical references.; Note: Online resource; title from PDF title page (EBSCO, viewed February 25, 2019).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.