Reviews of physiology, biochemistry and pharmacology. 176 (2019)

• Record Type: Book
• Further Information: Note: Bernd Nilius, Pieter de Tombe, Thomas Gudermann, Reinhard Jahn, Roland Lill, editors.
• Editors: Nilius, B; Tombe, Pieter de; Gudermann, Thomas; Jahn, Reinhard, 1950-; Lill, Roland
• Contents: Intro; Contents; DUSP3/VHR: A Druggable Dual Phosphatase for Human Diseases; 1 Introduction; 2 Protein Tyrosine Phosphatase (PTP); 2.1 Dual-Specificity Phosphatase (DUSP); 2.2 ADUSP; 2.3 DUSP3/VHR; 3 Molecular and Biological Functions of DUSP3/VHR; 3.1 DUSP3 in Tumorigenesis; 3.2 DUSP3 in Genomic Stability; 3.3 DUSP3 in Blood-Associated Diseases; 4 Overview of Current Knowledge on DUSP3/VHR Inhibitors; 5 Conclusions; References; Oncotic Cell Death in Stroke; 1 Introduction; 2 Pathways of Sodium Influx in Stroke; 2.1 Na+/K+-ATPase; 2.2 Glutamate Receptor Channels 2.3 Acid-Sensing Ion Channels (ASICs)2.4 Na+/H+ Exchanger (NHE); 2.5 Electrogenic Na+/HCO3- Co-transporter 1 (NBCe1); 2.6 Transient Receptor Potential (TRP) Channels; 3 Pathways of Chloride Influx in Stroke; 3.1 Na+-K+-2Cl- Co-transporter 1 (NKCC1); 4 Pathways of Potassium Efflux in Stroke; 4.1 KCNQ (Kv7) K+ Channels; 4.2 ATP-Dependent K+ Channels (KATP Channels); 5 Aquaporins (AQPs); 6 Mitochondrial Dysfunction; 7 Key Challenges and Future Directions; 8 Conclusion; References; Magnesium Extravaganza: A Critical Compendium of Current Research into Cellular Mg2+ Transporters Other than TRPM6/7 1 Introduction1.1 Toward the Identification of Mammalian/Human Mg2+ Transporters/Mg2+ Homeostatic Factors; 2 Novel Mammalian Magnesiotropic Genes Encode for Electrogenic Mg2+ Transporters (Channels) When Expressed in Xenopus laevis O...; 3 Expression Profiles of Novel Magnesiotropic Genes and Their Protein Products; 4 Cellular Compartmentalization and Functional Characterization of Proteins Encoded by the Putative and Confirmed Mg2+ Transpo...; 4.1 Mg2+ Transporters and/or Mg2+ Homeostatic Factors Localized to Mitochondria 4.2 Mg2+ Transporters and/or Mg2+ Homeostatic Factors Localized to Endoplasmic Reticulum4.3 Mg2+ Transporters and/or Mg2+ Homeostatic Factors Localized to the Golgi Apparatus; 4.4 Mg2+ Transporters and/or Mg2+ Homeostatic Factors Localized to Lysosomes; 4.5 Mg2+ Transport Across Nuclear Membrane; 4.6 Putative and Confirmed Mg2+ Transporters/Mg2+ Homeostatic Factors with Unclear Localization; 4.6.1 SLC41A2 (Solute Carrier Family 41 Member A2); 4.6.2 The CNNM (Cyclin and CBS Domain Divalent Metal Cation Transport Mediator) Family, ``Enfant terrible ́́Among Mg2+ Transpo... CNNM2 (Cyclin and CBS Domain Divalent Metal Cation Transport Mediator 2)CNNM4 (Cyclin and CBS Domain Divalent Metal Cation Transport Mediator 4); CNNM1 and CNNM3 (Cyclin and CBS Domain Divalent Metal Cation Transport Mediator3 and 4); 4.7 Putative and Confirmed Mg2+ Transporters/Mg2+ Homeostatic Factors with Plasma Membrane Localization; 4.7.1 SLC41A1 (Solute Carrier Family 41 Member A1); 4.7.2 KelI/XK; 4.7.3 NIPA1-NIPA4 (Non-imprinted in Prader-Willi/Angelman Syndrome 1-4)
• Publisher Details: Cham, Switzerland : Springer
• Publication Date: 2019
• Extent: 1 online resource (v, 131 pages), illustrations (some color)
• Subjects: 612; Human physiology; Molecular biology; Metabolism -- Disorders; Electronic books; Electronic books
• Languages: English
• ISBNs: 9783030140274
• Related ISBNs: 303014027X; 9783030140267
• Notes: Note: Online resource; title from PDF title page (SpringerLink, viewed April 11, 2019).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.