Regulation of signal transduction in human cell research. (2018)

• Record Type: Book
• Further Information: Note: Nariyoshi Shinomiya, Hiroaki Kataoka, Qian Xie, editors.
• Editors: Shinomiya, Nariyoshi; Kataoka, Hiroaki; Xie, Qian
• Contents: Chapter 1. Using genetically engineered mouse models to study wnt signaling in bone development and disease -- Chapter 2. Role of the receptor-mediated signaling pathways on the proliferation and differentiation of pluripotent stem cells -- Chapter 3. Regulation of microRNA expression by growth factors in tumor development and progression -- Chapter 4. Regulation of EMT by TGF-ß signaling in cancer cells -- Chapter 5. The functional interplay between pro-oncogenic RUNX2 and hypoxia-inducible factor-1a (HIF-1a) during hypoxia-mediated tumor progression -- Chapter 6. DNA damage: cellular responses, repair, and cancer treatment -- Chapter 7. Met activation and carcinogenesis -- Chapter 8. The HGF/MET signalling and therapeutics in cancer -- Chapter 9. Pericellular activation of peptide growth factors by serine proteases -- Chapter 10. Molexcular designing of small-molecule inhibitors for apoptosis regulation. Intro; Preface; Contents; Chapter 1: Using Genetically Engineered Mouse Models to Study Wnt Signaling in Bone Development and Disease; 1.1 Wnt/β-Catenin Signaling; 1.2 Wnt/β-Catenin Signaling in Human Skeletal Diseases; 1.3 Transgenic and Germ Line Knockout Models; 1.4 Bone-Specific Conditional Knockout Models; 1.4.1 Bone-Specific Promoters; 1.4.2 Osteoblast-Specific Knockouts; 1.4.3 Chondrocyte-Specific Knockouts; 1.4.4 Osteoclast-Specific Knockouts; 1.5 Gain-of-Function Mutations and Transgenic Models. 1.6 Detection of Wnt/β-Catenin Signaling Change in Genetically Modified Animals1.7 Conclusion; References; Chapter 2: Role of the Receptor-Mediated Signaling Pathways on the Proliferation and Differentiation of Pluripotent Stem Cells; 2.1 Introduction; 2.2 Role of the Receptor Signaling Pathways on Proliferation of Pluripotent Stem Cells; 2.3 Role of Receptor Signaling Pathways in Differentiation of Pluripotent Stem Cells into Cardiovascular Progenitor Cells. 2.4 Role of Receptor Signaling Pathways in the Differentiation of Pluripotent Stem Cells into Neural Progenitor Cells2.5 Closing Remarks; References; Chapter 3: Regulation of microRNA Expression by Growth Factors in Tumor Development and Progression; 3.1 Introduction; 3.2 Signal Transduction and Functions of Growth Factors; 3.3 Biogenesis and Functions of microRNAs; 3.4 Growth Factors and their Receptors Regulated by microRNAs; 3.5 microRNAs Regulated by Hepatocyte Growth Factor (HGF); 3.6 microRNAs Regulated by Other Growth Factors. 3.7 Growth Factor and microRNA Crosstalk Network3.8 Concluding Remarks; References; Chapter 4: Regulation of EMT by TGF-β Signaling in Cancer Cells; 4.1 Canonical and Noncanonical Signaling of TGF-β; 4.2 Dual Roles of TGF-β Signaling in Cancer; 4.3 Transcriptional Factors in the EMT; 4.4 Phosphorylation of Snail and ÎÉF1 During EMT; 4.5 Upregulation of Snail and ÎÉF1 by TGF-β; 4.6 Synergistic Induction of EMT by TGF-β and Other Signals; 4.7 Regulation of the EMT at the RNA Level; 4.8 Epigenetic Regulation of EMT Regulators; References. Chapter 5: The Functional Interplay Between Pro-oncogenic RUNX2 and Hypoxia-Inducible Factor-1α (HIF-1α) During Hypoxia-Mediated Tumor Progression5.1 Introduction; 5.2 Hypoxia-Inducible Factor-1 (HIF-1) and Hypoxic Response of Tumor Cells; 5.3 Maintenance and Propagation of Cancer Stem Cells (CSCs) Under Hypoxia; 5.4 Regulatory Role of MicroRNAs in Response to Hypoxia; 5.5 Pro-oncogenic Property of Runt-Related Transcription Factor 2 (RUNX2); 5.6 Functional Implication of RUNX2 in the Regulation of the Hypoxic Response; 5.7 Future Therapeutic Strategy Targeting Hypoxic Response.
• Publisher Details: Singapore : Springer
• Publication Date: 2018
• Extent: 1 online resource
• Subjects: 571.7/4; Cellular signal transduction; SCIENCE -- Life Sciences -- Anatomy & Physiology; Cellular signal transduction; Medicine & Public Health; Oncology; Medical Biochemistry; Cancer Research; Mechanotransduction, Cellular; Electronic books
• Languages: English
• ISBNs: 9789811072963; 9811072965
• Related ISBNs: 9789811072956; 9811072957
• Notes: Note: Includes bibliographical references.; Note: Online resource; title from PDF title page (EBSCO, viewed February 19, 2018).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.