RUNX proteins in development and cancer. ([2017])

• Record Type: Book
• Further Information: Note: Yoram Groner, Yoshiaki Ito, Paul Liu, James C. Neil, Nancy A. Speck, Andre van Wijnen, editors.
• Editors: Groner, Yoram; Ito, Yoshiaki; Liu, Pu Paul; Neil, James C; Speck, Nancy A; Van Wijnen, Andre J
• Contents: Evolution of RUNX genes. RUNX in invertebrates / S. Hughes, A. Woollard -- RUNX and CBF[beta] structure and biophysics of CBF[beta]/RUNX and its translocation products / Tahir H. Tahirov, John Bushweller -- Covalent modifications of RUNX proteins: structure affects function / Ezra Blumenthal, Sarah Greenblatt, Guang Huang, Koji Ando, Ye Xu, Stephen D. Nimer -- RUNX genes and mammalian development. The role of Runx1 in embryonic blood cell formation / Amanda D. Yzaguirre, Marella F.T.R. de Bruijn, Nancy A. Speck -- Runx1 structure and function in blood cell development / Constanze Bonifer, Elena Levantini, Valerie Kouskoff, Georges Lacaud -- Roles of Runx2 in skeletal development / Toshihisa Komori -- Mitotic gene bookmarking: an epigenetic mechanism for coordination of lineage commitment, cell identity and cell growth / Sayyed K. Zaidi, Jane B. Lian, Andre van Wijnen, Janet L. Stein, Gary S. Stein -- Roles of Runx genes in nervous system development / Jae Woong Wang, Stefano Stifani -- Runx family genes in tissue stem cell dynamics / Chelsia Qiuxia Wang, Michelle Meng Huang Mok, Tomomasa Yokomizo, Vinay Tergaonkar [and others] -- Roles of the RUNX1 enhancer in normal hematopoiesis and leukemogenesis / Wei-Siang Liau, Phuong Cao Thi Ngoc, Takaomi Sanda -- RUNX1 and CBF[beta] fusion proteins in leukemia. RUNX1-ETO leukemia / Shan Lin, James C. Mulloy, Susumu Goyama -- Clinical relevance of RUNX1 and CBFB alterations in acute myeloid leukemia and other hematological disorders / Klaus H. Metzeler, Clara D. Bloomfield -- Mechanism of ETV6-RUNX1 leukemia / Aishwarya Sundaresh, Owen Williams -- ETV6-RUNX1 + acute lymphoblastic leukaemia in identical twins / Anthony M. Ford Ph. D., Mel Greaves FRS -- Molecular basis and targeted inhibition of CBF[beta]-SMMHC acute myeloid leukemia / Lucio H. Castilla, John H. Bushweller -- RUNX and CBF[beta] in cancer and immune function. The RUNX genes as conditional oncogenes: insights from retroviral targeting and mouse models / James C. Neil, Kathryn Gilroy, Gillian Borland, Jodie Hay, Anne Terry, Anna Kilbey -- RUNX1 and CBF[beta] mutations and activities of their wild-type alleles in AML / R. Katherine Hyde, Paul Liu, Alan D. Friedman -- Roles of RUNX in B cell immortalisation / Michelle J. West, Paul J. Farrell -- Roles of RUNX in Solid Tumors / Linda Shyue Huey Chuang, Kosei Ito, Yoshiaki Ito -- RUNX3 and p53: how two tumor suppressors cooperate against oncogenic ras? / Jung-Won Lee, Andre van Wijnen, Suk-Chul Bae -- RUNX and CBF[beta] in cancer and immune function. Runx3 and cell fate decisions in pancreas cancer / Martin C. Whittle, Sunil R. Hingorani -- Runx genes in breast cancer and the mammary lineage / Nicholas Rooney, Alessandra I. Riggio, Daniel Mendoza-Villanueva, Paul Shore [and others] -- Runx3 in immunity, inflammation and cancer / Joseph Lotem, Ditsa Levanon, Varda Negreanu, Omri Bauer, Shay Hantisteanu [and others] -- Roles of RUNX complexes in immune cell development / Takashi Ebihara, Wooseok Seo, Ichiro Taniuchi -- CBF[beta] and HIV infection / Dong Young Kim, John D. Gross -- Emerging roles for RUNX. Roles of RUNX in hippo pathway signaling / Antonino Passaniti, Jessica L. Brusgard, Yiting Qiao, Marius Sudol [and others] -- Roles of RUNX in hypoxia-induced responses and angiogenesis / Sun Hee Lee, Sarala Manandhar, You Mie Lee -- The emerging roles of RUNX transcription factors in epithelial-mesenchymal transition / Dominic Chih-Cheng Voon, Jean Paul Thiery -- A regulatory role for RUNX1, RUNX3 in the maintenance of genomic integrity / Vaidehi Krishnan, Yoshiaki Ito.
• Publisher Details: Singapore : Springer
• Publication Date: 2017
• Copyright Date: 2017
• Extent: 1 online resource (xx, 515 pages), illustrations (chiefly color)
• Subjects: 572.8/6; DNA-binding proteins -- Cancer -- Research; Life sciences; SCIENCE -- Life Sciences -- Biology; Life sciences; Biomedicine; Gene Function; Oncology; Protein Science; Core Binding Factor alpha Subunits -- genetics; Core Binding Factor alpha Subunits -- metabolism; Core Binding Factor beta Subunit -- genetics; Core Binding Factor beta Subunit -- metabolism; Neoplasms -- genetics; Electronic books; Electronic books
• Languages: English
• ISBNs: 9789811032332; 9811032335
• Related ISBNs: 9789811032318; 9811032319
• Notes: Note: Includes bibliographical references and index.; Note: Online resource; title from pdf title page (SpringerLink, viewed March 20, 2017).; Note: Print version record.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.