Bone marrow stem cell therapy for stroke. (2017)

• Record Type: Book
• Further Information: Note: Kunlin Jin, Xunming Ji, Qichuan Zhuge, editors.
• Editors: Jin, Kunlin; Ji, Xunming; Zhuge, Qichuan
• Contents: Dedication; Preface; Contents; Contributors; Chapter 1: Ischemic Stroke Pathophysiology and Cell Therapy; 1.1 Introduction; 1.2 Pathophysiology of Ischemic Stroke; 1.2.1 Thrombosis; 1.2.2 Embolism; 1.2.3 Systemic Hypoperfusion; 1.2.4 Cellular Pathophysiology; 1.2.5 Cell Death After Stroke; 1.2.6 Mechanisms of Necrotic Cell Death; 1.2.7 Mechanisms of Programmed Cell Death; 1.3 Types of Stem Cells Used in Experimental Ischemic Stroke Therapy; 1.3.1 Embryonic Stem Cells (ESCs); 1.3.2 Mesenchymal Stem Cells (MSCs); 1.3.3 Bone Marrow-Derived MSCs (BMSCs). 1.3.4 Adipose-Derived Mesenchymal Stem Cells (AD-MSCs)1.3.5 Placenta-Derived Mesenchymal Stem Cells (PD-MSCs); 1.3.6 Induced Pluripotent Stem Cells (iPSCs); 1.3.6.1 Cell Therapy Using iPSCs for Stroke; 1.3.6.2 Mechanism of iPSC Therapy in Stroke; 1.3.7 Endothelial Progenitor Cells (EPCs); 1.3.7.1 Mechanism of EPC Therapy in Stroke; 1.3.8 Neural Stem Cells; 1.3.8.1 The Attempts to Treat Stroke with NSCs; 1.3.8.2 Underlying Mechanisms; References; Chapter 2: Bone Marrow Stem Cells: Source, Characterization, Isolation, Culture, and Identification; 2.1 Introduction; 2.2 Source. 2.2.1 Mesenchymal Stem Cells2.2.2 Hematopoietic Stem Cells; 2.2.3 Endothelial Progenitor Cells; 2.3 Characterization and Identification; 2.3.1 MSCs; 2.3.1.1 Morphology and Cell Cycle Study; 2.3.1.2 Differentiation Capacity; 2.3.1.3 Function; 2.3.1.4 Phenotype and Identification; 2.3.2 HSCs; 2.3.2.1 Multipotency; 2.3.2.2 Self-Renewal; 2.3.2.3 Markers and Identification; 2.3.3 EPCs; 2.3.3.1 Regenerative Potential of EPCs; 2.3.3.2 Phenotype and Identification; 2.4 Isolation; 2.4.1 MSCs; 2.4.2 HSCs; 2.4.3 EPCs; 2.5 Culture; 2.5.1 MSCs; 2.5.2 EPCs; 2.6 Conclusion; References. Chapter 3: Mobilization and Homing of Bone Marrow Stem Cells After Stroke3.1 Introduction; 3.2 Bone Mesenchymal Stem Cells; 3.2.1 The Characterization of BMSCs; 3.2.2 BMSC Mobilization After Stroke; 3.2.3 The Potential Signaling Pathway/Mechanisms Underlying BMSC Homing; 3.2.3.1 MCP-1; 3.2.3.2 CD44 and Selectin; 3.2.4 BMSCs Induced Neurotrophic Factor Secretion and Restoration of Neural Function; 3.3 Bone Marrow-Derived Hematopoietic Stem Cells; 3.3.1 The Characterization of HSCs and the Niches; 3.3.1.1 The Characterization of HSCs; 3.3.1.2 The HSC Niches; 3.3.2 HSC Mobilization After Stroke. 3.3.2.1 Mechanisms of HSPC Mobilization After Stroke3.3.2.1.1 The SDF-1/CXCR4 Interaction; 3.3.2.1.2 Interplays of the Sympathetic Nervous System with SDF-1/CXCR4 and G-CSF; 3.3.2.2 Agents That Enhance the Mobilization of HSCs for Stroke; 3.3.3 HSC Homing to the Ischemic Brain; 3.3.3.1 Mechanisms of HSC Homing After Stroke; 3.3.3.2 Methods of Enhancing HSC Homing to Ischemic Brain; 3.3.4 Regulations of HSC on Neural Restoration and Neural Function After Stroke; 3.4 Bone Marrow-Derived Endothelial Progenitor Cells; 3.4.1 Characteristics of EPCs; 3.4.1.1 EPCs and Angiogenesis.
• Publisher Details: Singapore : Springer
• Publication Date: 2017
• Extent: 1 online resource
• Subjects: 616.02/774; Mesenchymal stem cells; Cerebrovascular disease -- Treatment; HEALTH & FITNESS -- Diseases -- General; MEDICAL -- Clinical Medicine; MEDICAL -- Diseases; MEDICAL -- Evidence-Based Medicine; MEDICAL -- Internal Medicine; Cerebrovascular disease -- Treatment; Mesenchymal stem cells; Life Sciences; Stem Cells; Neurosciences; Electronic books
• Languages: English
• ISBNs: 9789811029295; 9811029296
• Related ISBNs: 9789811029288; 9811029288
• Notes: Note: Includes bibliographical references and index.; Note: Online resource; title from PDF title page (SpringerLink, viewed December 21, 2016).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.