Nucleic acid sensing and immunity. Part B (2019)

• Record Type: Book
• Further Information: Note: Edited by Claire Vanpouille-Box, Lorenzo Galluzzi.
• Editors: Vanpouille-Box, Claire; Galluzzi, Lorenzo
• Contents: Front Cover; Nucleic Acid Sensing and Immunity -- Part B; Copyright; Contents; Contributors; Nucleic Acid Sensing at the Interface Between Innate and Adaptive Immunity; Acknowledgments; Disclosures; References; Chapter One: Nucleic Acid Sensing in Allergic Disorders; 1. Introduction; 2. Categorizing Nucleic Acid Sensing Receptors Based on Mechanisms of Action (Table 1); 2.1. Group I Nucleic Acid Sensing Receptors; 2.1.1. TLRs, Membrane-Bound Pattern Recognition Receptors; 2.1.2. NLRs and Nucleic Acid Sensing; 2.1.3. AIM2 and cGAS; 2.2. Group II Nucleic Acid Sensing Receptors 2.3. Group III Nucleic Acid Sensing Receptors: RLRs3. Immune System and Nucleic Acid Sensing; 3.1. Nucleic Acid Sensing by Dendritic Cells; 3.2. Nucleic Acid Sensing by CD4 T Cells; 3.3. Nucleic Acid Sensing by B Cells; 4. Nucleic Acid Sensing by Epithelial Cells; 5. Viral Illness and Acute Asthma Exacerbations; 5.1. Rhinovirus; 5.2. Influenza Virus; 5.3. Respiratory Syncytial Virus (RSV); 6. Nucleic Acid-Based Therapies for Allergic Disorders; 7. Conclusions; Acknowledgment; References; Chapter Two: The Role of Nucleic Acid Sensing in Controlling Microbial and Autoimmune Disorders 1. Introduction2. RNA Nucleic Acid Sensing in Viral Immunology and Autoimmunity; 2.1. Detection of Intracellular RNA; 2.1.1. Protein Kinase R; 2.1.2. Toll-Like Receptors; 2.1.3. RIG-I-Like Receptors; 2.2. RNA Sensing During Viral Infections; 2.2.1. Hepatitis C Virus; 2.2.2. Dengue Virus and West Nile Virus; 2.2.3. Zika Virus; 2.2.4. Respiratory Syncytial Virus; 2.2.5. Nipah Virus; 2.2.6. Ebola Virus; 2.2.7. Rotavirus; 2.3. Defects in RNA Sensing and Autoimmunity; 2.3.1. The Role of MDA5 in Type 1 Diabetes and Aicardi-Goutières Syndrome; 2.3.2. P58, PERK, TLRs, and Type 1 Diabetes 2.3.3. Implication of RIG-I in Crohnś Disease2.3.4. Singleton-Merten Syndrome, Systemic Lupus Erythematosus, and Prolidase Disorder; 3. Intracellular Recognition of DNA; 3.1. A Central DNA-Sensing Pathway via cGAS and STING; 3.2. STING-Dependent Sensors: DDX41, Ku70, MRE11, and LSm14A; 3.2.1. DDX41; 3.2.2. Ku70; 3.2.3. MRE11; 3.2.4. LSm14A; 3.3. STING-Independent DNA Sensors: TLR9, RNA Polymerase III, DHX9/DHX36, AIM2, IFI16, Sox2, LRRFIP1, and Rad50; 3.3.1. TLR9; 3.3.2. RNA Polymerase III; 3.3.3. DHX9/DHX36; 3.3.4. AIM2 and IFI16; 3.3.5. Sox2, LRRFIP1, and Rad50 3.4. Autoimmune and Autoinflammatory Disorders Derived From Immune System Dysfunction3.5. DNA-Sensing Molecular Mechanisms of Diseases and Nucleic Acid Accumulation; 3.5.1. TLR9, TREX1, RNase H2, and SAMHD1; 3.5.2. Sjögrenś Syndrome; 3.6. Hypersensitivity of cGAS/STING Signaling; 3.6.1. SAVI and Familial Chilblain Lupus; 3.6.2. S6K1 and Multiple Sclerosis; 4. Prospective; Acknowledgments; References; Chapter Three: Nucleic Acid Induced Interferon and Inflammasome Responses in Regulating Host Defense to Gastrointestinal V ...; 1. The Viral Dimension of the Gut Microbiome
• Publisher Details: Cambridge, MA : Academic Press
• Publication Date: 2019
• Extent: 1 online resource
• Subjects: 572.8; Nucleic acids; Nucleic acids -- Regulation; RNA; SCIENCE / Life Sciences / Biochemistry; Electronic books; Electronic books
• Languages: English
• ISBNs: 9780128159828; 0128159820
• Related ISBNs: 9780128159811; 0128159812
• Notes: Note: Includes bibliographical references.; Note: Online resource; title from PDF title page (EBSCO, viewed February 26, 2019).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.