Reproducibility in biomedical research : epistemological and statistical problems /: epistemological and statistical problems. (2019)

• Record Type: Book
• Further Information: Note: Erwin B. Montgomery, Jr.
• Authors: Jr, Montgomery, Erwin B
• Contents: Front Cover; Reproducibility in Biomedical Research; Copyright Page; Dedication; Quote; Contents; Preface; Prologue; 1 Introduction; Science as Argumentation Within the Experiment and Within the Community; Scientific Argumentation and Logic; The Multifaceted Notion of Irreproducibility; Productive Irreproducibility; Ontology Versus Epistemology; The Use of Logical Formalism; Summary; 2 The Problem of Irreproducibility; Type I and II Errors; Controlling the Inevitability of Irreproducibility Risk; Institutional Responses; Reproducibility and Irreproducibility Contributions of Logic to Biomedical ResearchReductionism and Conceptual (Broad) Irreproducibility; Variability, Central Tendency, Chaos, and Complexity; Conceptual Reproducibility and the Importance of Hypothesis Generation; Summary; 3 Validity of Biomedical Science, Reproducibility, and Irreproducibility; Science Must Be Doing Something Right and Therein Lies Reproducibility and Productive Irreproducibility; Science Versus Human Knowledge of It; The Necessity of Enabling Assumptions; The Centrality of Reproducibility; The Central Tendency; The Scientific Method; Reductionism; Causality Special Cases of Irreproducible ReproducibilityScience as Inference to the Best Explanation; Summary; 4 The Logic of Certainty Versus the Logic of Discovery; Certainty, Reproducibility, and Logic; Deductive Logic-Certainty and Limitations; Syllogistic Deduction; Judicious Use of the Fallacy of Four Terms; Partial, Probability, Practical, and Causal Syllogisms; Propositional Logic; Induction; The Duhem-Quine Thesis; Summary; 5 The Logic of Probability and Statistics; The Value of the Logical Perspective in Probability and Statistics Metaphysics: Ontology Versus Epistemology and Biomedical ReproducibilityIndependence of Probabilities and Regression Toward the Mean; Avoiding the Fallacy of Four Terms; The Conflation of Ontology and Epistemology; Summary; 6 Causation, Process Metaphor, and Reductionism; Practical Syllogism and Beyond; Centrality of Hypothesis to Experimentation and Centrality of Causation to Hypothesis Generation; Reductionism and the Fallacies of Composition and Division; Other Fallacies as Applied to Cause; Discipline in the Principle of Causational and Informational Synonymy; Summary 7 Case Studies in Clinical Biomedical ResearchForbearance of Repetition; Setting the Stage; Clinical Meaningfulness; Statistics and Internal Validity; Establishing Clinical Meaningfulness; Specific Features to Look for in Case Studies; Case Study-Two Conflicting Studies of Hormone Use in Postmenopausal Women, Which Is Irreproducible?; Summary; 8 Case Studies in Basic Biomedical Research; Forbearance of Repetition; Purpose; Setting the Stage; The Value of a Tool from Its Intended Use; What is Basic Biomedical Research?; Scientific Meaning Versus Statistical Significance
• Publisher Details: London, United Kingdom : Academic Press, an imprint of Elsevier
• Publication Date: 2019
• Extent: 1 online resource
• Subjects: 570.72/4; Biology -- Research; Medicine -- Research; Reproducible research; NATURE / Reference; SCIENCE / Life Sciences / Biology; SCIENCE / Life Sciences / General; Electronic books; Electronic books
• Languages: English
• ISBNs: 9780128176726; 0128176725
• Related ISBNs: 9780128174432; 0128174439
• Notes: Note: Includes bibliographical references and index.; Note: Online resource; title from PDF title page (ScienceDirect, viewed March 19, 2019).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.