Progranulin and Central Nervous System Disorders. (2019)

• Record Type: Book
• Further Information: Note: Editors, Hideaki Hara [and 4 others].
• Editors: Hara, Hideaki
• Other Names: Hosokawa, Masato; Nakamura, Shinsuke; Shimohata, Takayoshi; Nishihara, Masugi
• Contents: Intro; Preface; Contents; Molecular and Functional Properties of Progranulin; Introduction; Structure of PGRN; Receptors and Signaling Pathways; Regulation of PGRN Expression; PGRN as a Growth Factor; PGRN as a Lysosomal Protein; Conclusion; References; Progranulin as a Potential Biomarker of Central Nervous System Disease; Introduction; Progranulin as a Biomarker of Neurodegenerative Diseases; Progranulin as a Biomarker of CNS Malignancies; Progranulin as a Biomarker of Autoimmune Neurological Disorders; Conclusion; References; Progranulin and Frontotemporal Lobar Degeneration; Introduction GRN Mutations and Pathological MechanismsPGRN Protein Is Not a Component of Ubiquitin-Positive Inclusion Bodies; Clinico-Pathological Characterization of GRN Mutation Carriers; Incidence Rate; Age of Onset; Clinicopathological Images of FTLD; PGRN Protein Levels in GRN Mutation Carriers; The Effect of GRN Mutation and Its Influence on PGRN; GRN Mutation: Multiple Proteinopathy?; References; PGRN and Neurodegenerative Diseases Other Than FTLD; Introduction; GRN Mutations and Neurodegenerative Diseases; GRN Mutations and Alzheimer's Disease; GRN Mutations and Parkinson's Disease Involvement of Lysosomes in Neurodegenerative Diseases Caused by GRN MutationsPGRN Trafficking into Lysosomes; PGRN in Negative Feedback Loop of Lysosomal Biogenesis; PGRN Functions in Lysosomes; Conclusion; References; Progranulin in Sexual Differentiation of the Developing Brain; Introduction; Sex Steroids and Sexual Differentiation of the Developing Brain; Identification of PGRN as a Sex Steroid-Inducible Gene; Changes and Localization of PGRN mRNA in the Neonatal Rat Brain; Intraventricular Injection of PGRN Antisense Oligodeoxynucleotide in Neonatal Male Rats
• Publisher Details: Place of publication not identified : Springer Nature Springer
• Publication Date: 2019
• Extent: 1 online resource
• Subjects: 572.6; Proteins; Glycoproteins; Neurogenetics; SCIENCE / Life Sciences / Biochemistry; Electronic books; Electronic books
• Languages: English
• ISBNs: 9789811361869
• Related ISBNs: 981136186X; 9789811361852; 9811361851
• Notes: Note: Online resource; title from PDF title page (EBSCO, viewed March 28, 2019).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.