Animal models of ophthalmic diseases. (2016)

• Record Type: Book
• Further Information: Note: Chi-Chao Chan, editor.
• Editors: Chan, Chi-Chao
• Contents: Foreword; Preface; Contents; Contributors; Chapter-1; Animal Models of Herpes Keratitis; 1.1 Introduction to Herpes Keratitis ; 1.2 HSV-1 Latency ; 1.3 HSV-1 Keratitis ; 1.3.1 HSV-1 Epithelial Keratitis; 1.3.2 Herpes Stromal Keratitis; 1.3.2.1 Neurotrophic Damage as a Major Component of HSK in Mice; 1.4 Allografts on Corneas with HSK ; References; Commentary; References; Chapter-2; Animal Models of Cataracts; 2.1 Introduction; 2.2 Models of Congenital Cataract; 2.2.1 Crystallins; 2.2.2 Connexins; 2.2.3 Cytoskeletal and Membrane Proteins; 2.3 Models of Age-Related Cataracts. 2.3.1 Diabetic Cataract2.3.2 UV-Induced Cataracts; 2.3.3 Steroid-Induced Cataracts; 2.3.4 Oxygen and Nuclear Cataracts; 2.4 Secondary Cataract; 2.5 Conclusion; References; Commentary; Chapter-3; Animal Models of Glaucoma; 3.1 Introduction; 3.2 Rodent Glaucoma Models; 3.3 Episcleral Vein Injection/Ablation; 3.4 Translimbal Laser Photocoagulation; 3.5 Microbead Injection; 3.6 Other Models of Induced Ocular Hypertension; 3.7 Genetic Mouse and Rat Models; 3.8 Primary Open-Angle Glaucoma Models; 3.9 Primary Angle-Closure Glaucoma Models; 3.10 Pigmentary Dispersion and Exfoliation Glaucoma Models. 3.11 Congenital and Developmental Glaucoma Models3.12 Future Possible Models; 3.13 Conclusions; References; Commentary; Chapter-4; Animal Models of Age-Related Macular Degeneration: Subretinal Inflammation; 4.1 Introduction; 4.2 Inflammation and Age-Related Macular Degeneration; 4.3 Subretinal Inflammation in AMD Animal Models ; 4.3.1 AMD-Associated Risk Factors and Inflammation; 4.3.1.1 Genetic Risk Factors; 4.3.1.2 AMD-Associated Environmental Risk Factors and Inflammation; 4.3.2.1 Suppression of Tonic Anti-Inflammatory Signals; 4.3.2.2 Defective Immunosuppressive Environment. 4.3.2.3 Autoimmune Reaction4.3.3 "Secondary inflammation" AMD Models; 4.4 Conclusion; References; Commentary; Commentary; Chapter-5; Animal Models of Diabetic Retinopathy; 5.1 Introduction and Clinical Context; 5.2 The Need for Animal Models to Understand the Pathophysiology of DR; 5.3 Rodent Models of DR; 5.3.1 Chemically Induced Diabetes in Mice and Rats; 5.3.2 Spontaneous Diabetic Rodents as Models of DR; 5.3.3 Diet-Induced DR in Rodents; 5.4 Dog Models of DR; 5.5 Other Large Animals of DR; 5.6 Non-mammalian Models of DR; 5.7 Models of PDR; 5.7.1 VEGF Overexpression. 5.7.2 Oxygen-Induced Retinopathy5.8 Techniques to Detect Retinal Lesion in Animal Models of Diabetes; 5.8.1 Fundus Colour Imaging; 5.8.2 Confocal Scanning Laser Ophthalmoscope (cSLO); 5.8.3 Optical Coherence Tomography (OCT); 5.8.4 Electroretinogarphy (ERG); 5.9 Conclusion; References; Commentary; Chapter-6; Animal Models of autoimmune uveitis; 6.1 Introduction; 6.2 Why Do We Need Animal Models to Study Human Uveitis?; 6.3 Animal Models of Uveitis Exhibit Clinical Heterogeneity, Similar to Human Uveitis; 6.4 Induced Animal Models of Uveitis; 6.4.1 Experimental Autoimmune Uveitis (EAU).
• Publisher Details: Cham : Springer
• Publication Date: 2016
• Extent: 1 online resource
• Subjects: 617.7/1; Eye -- Diseases -- Animal models; MEDICAL -- Surgery -- General; Eye -- Diseases -- Animal models; Medicine & Public Health; Ophthalmology; Animal Models; Ocular Physiological Phenomena; Models, Animal; Electronic books
• Languages: English
• ISBNs: 9783319194349; 3319194348
• Related ISBNs: 9783319194332; 331919433X; 9783319194332
• Notes: Note: Includes bibliographical references and index.; Note: Online resource; title from PDF title page (EBSCO, viewed December 9, 2015).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.