Bone adaptation : in silico approach /: in silico approach. (2018)
- Record Type:
- Book
- Title:
- Bone adaptation : in silico approach /: in silico approach. (2018)
- Main Title:
- Bone adaptation : in silico approach
- Further Information:
- Note: Yoshitaka Kameo, Ken-ichi Tsubota, Taiji Adachi.
- Authors:
- Kameo, Yoshitaka
Tsubota, Ken-ichi
Adachi, Taiji - Contents:
- Intro; Preface; Contents; Chapter 1: Overview: In Silico Approaches to Understand Bone Adaptation; 1.1 Introduction; 1.2 Modeling Bone Adaptation from Cellular to Tissue Level; 1.3 Modeling Bone Adaptation from Tissue to Organ Level; 1.4 Open Questions and Future Directions; 1.4.1 Osteocyte Mechanotransduction; 1.4.2 Osteocyte Morphology; 1.4.3 Signaling in Bone Metabolism; 1.5 Conclusion; References; Chapter 2: Microscopic Fluid Flow Analysis in an Osteocyte Canaliculus; 2.1 Introduction; 2.2 Three-Dimensional Reconstruction of Osteocytes in Canaliculi; 2.3 Computational Fluid Flow Analysis. 2.4 Model of Osteocyte Canaliculi2.5 Interstitial Fluid Flow in Osteocyte Canaliculi; 2.6 Importance of Canalicular Microstructure in Osteocyte Mechanosensing; 2.7 Conclusion; References; Chapter 3: Macroscopic Fluid Flow Analysis in a Poroelastic Trabecula; 3.1 Introduction; 3.2 Theory of Poroelasticity; 3.2.1 Constitutive Relations; 3.2.2 Governing Equations; 3.3 Poroelastic Modeling of a Single Trabecula; 3.3.1 Formulation of Poroelastic Problem; 3.3.2 Analytical Solution for Fluid Pressure; 3.4 Interstitial Fluid Pressure in Trabecula; 3.4.1 Description of Fluid Pressure Behavior. 3.4.2 Steady-State Response3.4.3 Transient Response; 3.5 Importance of Transient Fluid Pressure Response; 3.6 Implications of Fluid Flow in Trabecular Bone Remodeling; 3.7 Conclusion; References; Chapter 4: Estimation of Bone Permeability for Poroelastic Analysis; 4.1 Introduction; 4.2 Confocal LaserIntro; Preface; Contents; Chapter 1: Overview: In Silico Approaches to Understand Bone Adaptation; 1.1 Introduction; 1.2 Modeling Bone Adaptation from Cellular to Tissue Level; 1.3 Modeling Bone Adaptation from Tissue to Organ Level; 1.4 Open Questions and Future Directions; 1.4.1 Osteocyte Mechanotransduction; 1.4.2 Osteocyte Morphology; 1.4.3 Signaling in Bone Metabolism; 1.5 Conclusion; References; Chapter 2: Microscopic Fluid Flow Analysis in an Osteocyte Canaliculus; 2.1 Introduction; 2.2 Three-Dimensional Reconstruction of Osteocytes in Canaliculi; 2.3 Computational Fluid Flow Analysis. 2.4 Model of Osteocyte Canaliculi2.5 Interstitial Fluid Flow in Osteocyte Canaliculi; 2.6 Importance of Canalicular Microstructure in Osteocyte Mechanosensing; 2.7 Conclusion; References; Chapter 3: Macroscopic Fluid Flow Analysis in a Poroelastic Trabecula; 3.1 Introduction; 3.2 Theory of Poroelasticity; 3.2.1 Constitutive Relations; 3.2.2 Governing Equations; 3.3 Poroelastic Modeling of a Single Trabecula; 3.3.1 Formulation of Poroelastic Problem; 3.3.2 Analytical Solution for Fluid Pressure; 3.4 Interstitial Fluid Pressure in Trabecula; 3.4.1 Description of Fluid Pressure Behavior. 3.4.2 Steady-State Response3.4.3 Transient Response; 3.5 Importance of Transient Fluid Pressure Response; 3.6 Implications of Fluid Flow in Trabecular Bone Remodeling; 3.7 Conclusion; References; Chapter 4: Estimation of Bone Permeability for Poroelastic Analysis; 4.1 Introduction; 4.2 Confocal Laser Scanning Imaging of Lacuno-Canalicular Porosity; 4.3 Theoretical Method for Estimating Bone Permeability; 4.3.1 Quantification of Canalicular Anisotropy; 4.3.2 Estimation of Trabecular Bone Permeability; 4.4 Application to Confocal Laser Scanning Imaging. 4.4.1 Quantification of Canalicular Anisotropy4.4.2 Estimation of Trabecular Bone Permeability; 4.5 Validation of the Estimated Bone Permeability; 4.6 Characteristics of the Proposed Estimation Method; 4.7 Conclusion; References; Chapter 5: Modeling Trabecular Bone Adaptation Induced by Flow Stimuli to Osteocytes; 5.1 Introduction; 5.2 Mathematical Model of Trabecular Bone Remodeling; 5.2.1 Theoretical Framework; 5.2.2 Cellular Mechanosensing; 5.2.3 Intercellular Signal Transmission; 5.2.4 Trabecular Surface Movement; 5.3 Voxel Modeling of a Single Trabecula under Cyclic Uniaxial Load. 5.4 Adaptation of a Single Trabecula to Cyclic Uniaxial Load5.4.1 Morphological Changes in Trabecula; 5.4.2 Quantitative Evaluation of Remodeling Process; 5.5 Characteristics of the Proposed Remodeling Model; 5.6 Validity of the Simulated Remodeling Process; 5.7 Conclusion; References; Chapter 6: Effects of Local Bending Load on Trabecular Bone Adaptation; 6.1 Introduction; 6.2 Voxel Modeling of a Single Trabecula under a Cyclic Bending Load; 6.3 Adaptation of a Single Trabecula to a Cyclic Bending Load; 6.4 Role of Local Bending Load in Bone Remodeling; 6.5 Conclusion; References. … (more)
- Publisher Details:
- Tokyo, Japan : Springer
- Publication Date:
- 2018
- Extent:
- 1 online resource
- Subjects:
- 612.7/51
Bones -- Adaptation
MEDICAL -- Physiology
SCIENCE -- Life Sciences -- Human Anatomy & Physiology
Bones -- Adaptation
Engineering
Biomedical Engineering
Orthopedics
Physiological, Cellular and Medical Topics
Biological and Medical Physics, Biophysics
Regenerative Medicine/Tissue Engineering
Simulation and Modeling
Electronic books
Electronic book - Languages:
- English
- ISBNs:
- 9784431565147
4431565140 - Related ISBNs:
- 9784431565123
4431565124 - Notes:
- Note: Includes bibliographical references and index.
Note: Online resource; title from PDF title page (SpringerLink, viewed January 18, 2018). - Access Rights:
- Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
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- British Library HMNTS - ELD.DS.403345
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