Advances in asthma : pathophysiology, diagnosis and treatment /: pathophysiology, diagnosis and treatment. ([2019])

• Record Type: Book
• Further Information: Note: Akihito Yokoyama, editor.
• Editors: Yokoyama, Akihito
• Contents: Intro; Preface; Contents; Part I: Pathophysiology; Chapter 1: Genetics in Asthma; 1.1 Introduction; 1.2 Association Studies; 1.2.1 Candidate Gene Association Studies; 1.2.2 Genome-Wide Association Studies; 1.3 Phenotypic Heterogeneity, Epistasis, Gene-Environment Interactions, and Epigenetics; 1.4 Conclusion; References; Chapter 2: Group 2 Innate Lymphoid Cells and Asthma; 2.1 Introduction; 2.1.1 Two Distinct Type-2 Immune Responses; 2.1.2 Group 2 Innate Lymphoid Cells (ILC2s); 2.2 ILC2s in Patients with Asthma (Table 2.1) 2.2.1 ILC2s Are Increased in the Peripheral Blood and Airways of Patients with Asthma2.2.2 Increased ILC2 Numbers and Activation in More Severe Forms of Asthma; 2.2.3 ILC2s Are Increased in Eosinophilic Asthma; 2.3 Corticosteroid Sensitivity of ILC2s; 2.3.1 Corticosteroid Sensitivity of Murine and Human ILC2s; 2.3.2 Murine and Human ILC2s Isolated from Asthmatic Airways Are Corticosteroid-Resistant; 2.3.3 Mechanism of Corticosteroid Resistance Induction in Murine and Human ILC2s; 2.4 Asthma Exacerbation due to Viral Infection and ILC2s 2.4.1 Airway IL-33/IL-25/TSLP Production During Viral Infection2.4.2 IL-33/IL-25/TSLP-Mediated Exacerbation of Airway Inflammation During Viral Infection; 2.4.3 IFN Response in Healthy and Asthmatic Airways During Viral Infection; 2.5 Conclusion; References; Chapter 3: Cellular Mechanisms of Allergic Airway Inflammation; 3.1 Introduction; 3.2 Airway Structural Cells; 3.2.1 Airway Epithelial Cells; 3.2.2 Airway Smooth Muscle Cells; 3.3 Innate and Adaptive Immune Cells; 3.3.1 Dendritic Cells (DCs) (Fig. 3.2); 3.3.2 CD4+ T cells; 3.3.2.1 Th2 Cells (Fig. 3.3); 3.3.2.2 Th1 Cells 3.3.2.3 Th17 Cells3.3.2.4 Regulatory T cells (Tregs); 3.3.3 Group 2 Lymphoid Cell, Innate Lymphoid Cells (ILCs) (Fig. 3.3); 3.4 Conclusion; References; Chapter 4: Mechanisms for Non-eosinophilic Asthma; 4.1 Introduction; 4.2 Cellular Profiles of Eosinophilic and Non-eosinophilic Asthma; 4.3 Clinical Characteristics of Non-eosinophilic Asthma; 4.4 Evidence for Neutrophil Activation in Asthma; 4.5 Mechanisms of Eosinophilic and Non-eosinophilic Asthma; 4.5.1 Mechanisms of Neutrophilic Asthma; 4.5.2 Mechanisms of Paucigranulocytic Asthma
• Publisher Details: Singapore : Springer
• Publication Date: 2019
• Extent: 1 online resource (187 p.)
• Subjects: 616.2/38; Asthma; Asthma -- Treatment; Asthma; Asthma -- Treatment; Electronic books
• Languages: English
• ISBNs: 9789811327902; 9811327904
• Related ISBNs: 9789811327896; 9811327890
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.