Cell biology of the ovary : stem cells, development, cancer, and clinical aspects /: stem cells, development, cancer, and clinical aspects. (2018)

• Record Type: Book
• Further Information: Note: Hidetaka Katabuchi, Takashi Ohba, Takeshi Motohara, editors.
• Editors: Katabuchi, Hidetaka; Ohba, T (Takeshi); Motohara, Takeshi
• Contents: Intro; Preface; Contents; 1: Reconstitution of Germ Cell Development In Vitro; 1.1 Introduction; 1.2 In Vitro Reconstitution of Mouse Germ Cell Development; 1.2.1 Signaling Pathways for the Specification of Mouse Primordial Germ Cells; 1.2.2 Induction of PGC-Like Cells (PGCLCs) from Mouse Pluripotent Stem Cells; 1.2.3 Completion of Mouse Oogenesis In Vitro; 1.2.4 Induction of Spermatogonia-Like Cells from PGCLCs; 1.2.5 Propagation of PGCLCs In Vitro; 1.3 Induction of Human Germ Cell Fate In Vitro; 1.3.1 In Vitro Systems to Induce Human PGCLCs from hPSCs. 1.3.2 Competence for the Induction of Human PGCLCs1.4 Future Perspectives for Reconstituting Human Germ Cell Development In Vitro; References; 2: The Role of Hedgehog-BMP4 Signaling in the Patterning of Coelomic Mesoderm and the Onset of Gonadogenesis; 2.1 Introduction; 2.1.1 Contrasting Cellular Behaviors in the Dorsal and Ventral Parts of Medial LPM at the Onset of Gonadogenesis; 2.1.2 Hedgehog (Hh) Signaling Establishes Dorsoventral Pattern in M-LPM and Initiates Gonadogenesis; 2.1.3 Dynamic Transition of BMP4 Expression and Roles at the Downstream of Hh Signaling in LPM. 2.1.4 Candidate Molecules Regulating Cellular Behaviors Involved in the Onset of Gonadogenesis Downstream of Hh-BMP4 SignalingReferences; 3: Regulation of Metabolic Pathways in Steroidogenic Cells by Ad4BP/SF-1; 3.1 Introduction; 3.1.1 Metabolic Pathways Activated in Steroidogenic Cells; 3.1.2 Implication of Ad4BP/SF-1 into Glycolytic Gene Regulation; 3.1.3 Implication of Ad4BP/SF-1 into NADPH Synthetic Gene Regulation; 3.1.4 Orchestration of Metabolic Pathways by a Single Transcription Factor; References. 4: Role of Lgr5-Expressing Stem Cells in Epithelial Renewal and Cancer in the Reproductive Tract4.1 Introduction; 4.2 Methods Employed to Identify and Characterise Reproductive Epithelial Stem Cells; 4.3 Lgr5+ Stem Cell Precursors Give Rise to Adult OSE and Cortical Granulosa Lineages; 4.4 Regulation of Lgr5+ Stem Cell-Driven OSE Regeneration: Intrinsic Versus Niche Signals; 4.5 Cancer of the Reproductive Tract: Lgr5+ OSE Stem Cells as Ovarian Cancer Origins; 4.6 Future Directions and Conclusion; References; 5: Tumor-Initiating Cells in Ovarian Cancer; 5.1 Introduction. 5.2 Stem Cells in the Normal Ovary and in Ovarian Cancer5.3 Redefining Reversible Quiescence as a Functional Property of CSCs Reappropriated Their Recognition as Tumor-Initiating Cells (TICs); 5.4 CSC/TIC Identification Through the Maze of Intra-Tumor Heterogeneity and Their Differential Regulation Under Conditions of Stress; 5.5 Future Perspectives; References; 6: Emerging Role of CD44 Variant 6 in Driving the Metastatic Journey of Ovarian Cancer Stem Cells; 6.1 Introduction; 6.2 Genomic and Protein Structure of CD44; 6.3 CD44 and Cancer Stemness.
• Publisher Details: Singapore : Springer
• Publication Date: 2018
• Extent: 1 online resource (viii, 166 pages), illustrations (some color)
• Subjects: 573.6/65; Ovaries; SOCIAL SCIENCE -- Anthropology -- Physical; Ovaries; Medicine & Public Health; Gynecology; Oncology; Reproductive Medicine; Electronic books
• Languages: English
• ISBNs: 9789811079412; 9811079412
• Related ISBNs: 9789811079405; 9811079404
• Notes: Note: Online resource; title from PDF title page (SpringerLink, viewed May 14, 2018).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.