Protein-protein and domain-domain interactions. (2018)

• Record Type: Book
• Further Information: Note: Pandjassarame Kangueane, Christina Nilofer.
• Authors: Kangueane, Pandjassarame; Nilofer, Christina
• Contents: 1. Introduction -- 2. Protein-protein binding -- 3. Low-resolution protein complexes -- 4. Heterodimer protein complexes -- 5. Homo multimer protein complexes -- 6. Hetero multimer protein complexes -- 7. Hot spots at the protein-protein interface -- 8. Principles of protein-protein interaction -- Databases for protein-protein interaction -- 10. Homodimer protein folding and binding -- 11. Protein subunit-subunit to domain-domain interactions -- 12. Domain-domain interactions -- 13. Protein-protein interaction tools -- 14. Protein-protein docking: Methods and tools -- 15. HLA-peptide interaction to short peptide vaccine design -- 16. Protein-protein interfaces and diseases -- 17. Patented protein structural complexes in discovery platform -- 18. Proteome-scale analysis of protein complexes -- 19. Conclusions and challenges -- Useful formula. Intro; Dedication; Preface; Acknowledgment; Contents; About the Authors; 1: Introduction; 1.1 Proteins; 1.2 Covalent Bond and Bond Length; 1.3 Disulfide Bond; 1.4 Protein Structure Representation; 1.5 Structural Motifs; 1.6 Protein Surface and Core; 1.7 Central Dogma of Molecular Biology; 1.8 Types of Proteins; 1.9 Multi-domain Protein; 1.10 Accessible Surface Area (ASA); 1.11 Protein-Protein Interface; 1.12 Interface Area; 1.13 Van Der Waals (vdW) Interactions; 1.14 Hydrogen Bonds; 1.15 Salt Bridges; Exercises; References; 2: Protein-Protein Binding. 2.1 Molecular Functions of Protein Complexes2.2 Homodimer Protein Complex; 2.3 Heterodimer Protein Complex; 2.4 Interface Hydrogen Bonds; 2.5 Interface Salt Bridges; 2.6 Interface Peptide Segment; 2.7 Principles of Protein-Protein Binding; Exercises; References; 3: Low-Resolution Protein Complexes; 3.1 Protein Complexes; 3.2 Protein Hetero Complexes; 3.2.1 AB Dimer Protein Complex; 3.2.2 A2B Trimer Protein Complex; 3.2.3 ABC Trimer Protein Complex; 3.2.4 ABCD Tetramer Protein Complex; 3.2.5 A2B2 Tetramer Protein Complex; 3.2.6 A3B3 Hexamer Protein Complex. 3.2.7 A2B2C2 Hexamer Protein Complex3.3 Protein Homo Complexes; 3.3.1 A2 Homodimer Protein Complex; 3.3.2 A3 Homo Trimer Protein Complex; 3.3.3 A4 Homo Tetramer Protein Complex; 3.3.4 A5 Homo Pentamer Protein Complex; 3.3.5 A6 Homo Hexamer Protein Complex; 3.3.6 A8 Homo Octamer Protein Complex; 3.3.7 A12 Homo Dodecamer Protein Complex; Exercises; References; 4: Heterodimer Protein Complexes; 4.1 Heterodimer Protein Complex; 4.2 Interface Size; 4.3 Interface Area and Interface Size; 4.4 Inter-residue Analysis of Complexes; 4.5 Nonpolar and Polar Interfaces. 4.6 Protein Complexes and Molecular Function4.7 Nonpolar and Polar Interfaces with Known Molecular Function; 4.8 Interface Size, Energy, and Function; 4.9 vdW, Interface Size, and Function; 4.10 Hydrogen Bonds, Interface Size, and Function; 4.11 Electrostatics, Interface Size, and Function; 4.12 Conclusion; Exercises; References; 5: Homo Multimer Protein Complexes; 5.1 Creation of Homo Multimer Protein Complex Dataset; 5.2 Distribution of Homo Multimer Protein Complexes; 5.3 Homo Trimer Protein Complexes; 5.4 Homo Tetramer Protein Complexes. 5.5 Homo Pentamer Protein Complexes5.6 Homo Hexamer Protein Complexes; 5.7 Homo Octamer Protein Complexes; 5.8 Homo Dodecamer Protein Complexes; Exercises; References; 6: Hetero Multimer Protein Complexes; 6.1 Creation of Hetero Multimer Protein Complex Dataset; 6.2 Distribution of Hetero Multimer Protein Complexes; 6.3 ABC Hetero Trimer Protein Complex; 6.4 A2B Hetero Trimer Protein Complex; 6.5 ABCD Hetero Tetramer Protein Complex; 6.6 A2B2 Hetero Tetramer Protein Complex; 6.7 A3B3 Hetero Hexamer Protein Complex; 6.8 A2B2C2 Hetero Hexamer Protein Complex; Exercises; References.
• Publisher Details: Singapore : Springer
• Publication Date: 2018
• Extent: 1 online resource (xix, 207 pages), illustrations (some color)
• Subjects: 572/.64; Protein-protein interactions; SCIENCE -- Life Sciences -- Biochemistry; Protein-protein interactions; Vaccine; Protein Interaction Domains and Motifs; Electronic books
• Languages: English
• ISBNs: 9789811073472; 9811073473
• Related ISBNs: 9789811073465; 9811073465
• Notes: Note: Includes bibliographical references.; Note: Online resource; title from PDF title page (SpringerLink, viewed February 19, 2018).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.