Hepatitis B virus and liver disease. (2018)

• Record Type: Book
• Further Information: Note: Jia-Horng Kao, Ding-Shinn Chen, editors.
• Editors: Kao, Jia-Horng; Chen, Ding-Shinn
• Contents: Intro; Foreword; Preface; Contents; List of Contributors; 1: Molecular Virology and Life Cycle; 1 Classification; 2 Structure of the Hepatitis B Virus; 2.1 Viral and Subviral Particles; 2.2 Genome Organization and Viral Proteins; 2.2.1 Pol ORF; 2.2.2 Pre-C/C ORF; HBc Protein; HBe Protein; 2.2.3 Pre-S/S ORF; SHBs; MHBs; LHBs; 2.2.4 X ORF; 3 Viral Life Cycle; 3.1 Attachment and Penetration; 3.2 Conversion of Genomic RC DNA into cccDNA and Transcriptional Activation of the Viral Minichromosome; 3.3 Genomic Replication via Reverse Transcription. 3.4 Virion Assembly and Release4 Variant Viruses; 4.1 Precore Mutants; 4.2 Basal Core Promoter Mutants; 4.3 Polymerase Mutants; 4.3.1 l-Nucleoside Analogue Resistance; 4.3.2 Acyclic Nucleoside Phosphonate Resistance; 4.3.3 d-Cyclopentane Resistance; 4.3.4 Multidrug Resistance; 4.4 Envelope Mutants; References; 2: Unmet Needs in Basic Research: In Vitro and In Vivo Models; 1 Introduction; 1.1 Hepatitis B Virus; 1.2 Woodchuck Hepatitis Virus; 1.3 Duck Hepatitis B Virus; 2 HBV In Vivo Experimental Models; 2.1 Chimpanzee Model; 2.2 Macaque Model; 2.3 Tupaia Model. 2.4 Transgenic Mice2.5 Human Hepatocyte Chimeric Mice; 2.6 Immune-Competent Mouse Models; 2.7 Hydrodynamic Injection HBV Mouse Model; 2.8 Adenovirus-Mediated Delivery; 3 HBV In Vitro Experimental Systems; 3.1 Primary Human Hepatocytes; 3.2 HepG2 Cells; 3.3 HepaRG Cells; 3.4 HepCHLine-4 Cells; 3.5 Identification of the HBV Receptor; 3.6 NTCP Expression as a Limiting Factor for HBV Infection; 3.7 NTCP-Expressing Cell Lines; 3.8 Human Hepatocytes Isolated from Humanized Mice; 3.9 Improvements to Primary Hepatocyte Culturing. 3.10 Hepatic Cell Lines Derived from Human-Induced Pluripotent Stem CellsReferences; 3: Immunopathogenesis of Hepatitis B Virus (HBV) Infection; 1 Characteristics of Immune Response in Acute-Resolved HBV Infection; 1.1 The Innate Immune Response; 1.1.1 HBV: Is It Sensed or Not by the Innate Immune System?; 1.1.2 NK Cells: The Main Force of Innate Immunity; 1.2 The Adaptive Immune Response; 1.2.1 B Cells; 1.2.2 T Cells; 2 Specialties of the Immune Response in Chronic HBV Infection; 2.1 The Innate Immune Response in CHB; 2.2 The Adaptive Immune Response in CHB. 2.2.1 B Cells2.2.2 T Cells: Functional Exhaustion; 3 Immune Response and Liver Injury; 3.1 HBV-Specific T Cells; 3.2 Non-HBV-Specific Cells; 4 Immune Response and Antiviral Treatment; References; 4: Epidemiology and Natural History of Chronic Hepatitis B Virus Infection; 1 Introduction; 2 Epidemiology; 2.1 CHB in Africa; 2.2 CHB in Asia and the Pacific Islands; 2.3 CHB in the Americas; 2.4 CHB in Europe; 3 HBV Genotypes; 4 Natural History; 5 Interpretation of Serologies; 6 HBV Structure and Replication Cycle; 7 Phases of Infection; References.
• Publisher Details: Singapore : Springer
• Publication Date: 2018
• Extent: 1 online resource
• Subjects: 616.3/623; Hepatitis B virus; Liver -- Diseases; HEALTH & FITNESS -- Diseases -- General; MEDICAL -- Clinical Medicine; MEDICAL -- Diseases; MEDICAL -- Evidence-Based Medicine; MEDICAL -- Internal Medicine; Hepatitis B virus; Liver -- Diseases; Electronic books
• Languages: English
• ISBNs: 9789811048432; 9811048436; 9811048428; 9789811048425
• Related ISBNs: 9789811048425
• Notes: Note: Online resource; title from PDF title page (SpringerLink, viewed January 18, 2018).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.