Pathogenesis of idiopathic scoliosis. (2018)

• Record Type: Book
• Further Information: Note: Masafumi Machida, Stuart L. Weinstein, Jean Dubousset, editors.
• Editors: Machida, Masafumi; Weinstein, Stuart L; Dubousset, Jean
• Contents: Intro; Foreword; Preface; Contents; Chapter 1: Definition of Adolescent Idiopathic Scoliosis; 1.1 Introduction; 1.1.1 First Statement; 1.1.2 Second Statement; 1.1.3 Third Statement; 1.2 Scoliosis; 1.2.1 Conclusion; 1.3 Adolescent Scoliosis; 1.4 Idiopathic Scoliosis; 1.5 Classification of Adolescent Idiopathic Scoliosis; 1.6 Personal Conclusion; References; Chapter 2: Adolescent Idiopathic Scoliosis: Natural History; 2.1 Introduction; 2.2 Etiopathogenesis; 2.3 Prevalence; 2.4 Diagnosis; 2.5 Early Studies on Patient Outcomes; 2.6 Curve Progression; 2.6.1 Skeletal Maturity. 2.6.1.1 Curve Factors2.6.1.2 Growth Factors; 2.6.2 Curve Location; 2.7 Back Pain and Disability; 2.8 Pulmonary Function; 2.9 Mortality; 2.10 Psychosocial Effects; 2.11 Pregnancy; 2.12 Summary; References; Chapter 3: The Genetic Architecture of Adolescent Idiopathic Scoliosis; 3.1 Introduction; 3.2 Epidemiology and Inheritance: How Common and 'Genetic' Is AIS?; 3.3 AIS: A Disease of Bone, Muscle, Nerve, or Cartilage?; 3.4 Identifying AIS Genes in Humans: Mapping Susceptibility Loci; 3.4.1 Family-Based Studies; 3.4.2 Population-Based Studies. 3.4.3 Population-Based Studies of Rare Mutations3.4.4 Chromosomal Breakpoint Mapping; 3.5 Candidate Genes and AIS Etiology; 3.5.1 LBX1; 3.5.2 GPR126; 3.5.3 BNC2; 3.5.4 PAX1 and PAX3; 3.5.5 SOX9; 3.5.6 Other Genes; 3.6 AIS Candidate Genes from Model Systems; 3.6.1 PTK7; 3.6.2 KIF6; 3.7 Quantitative Analyses: Do Genetic Factors Influence Disease Course?; 3.8 AIS Genetics: Ongoing and Future Research; 3.8.1 Genomic Studies; 3.8.2 Epigenetics; 3.8.3 Disease Modeling in Animals; 3.9 Summary; References; Chapter 4: Biomechanics of Adolescent Idiopathic Scoliosis; 4.1 Introduction. 4.1.1 Principles of 3D Reconstruction from Biplanar X-rays4.1.2 Clinical Relevance of 3D Reconstruction from Biplanar X-rays; 4.2 Focus on Vertebrae and Intervertebral Discs; 4.2.1 Vertebrae; 4.2.2 Intervertebral Discs; 4.2.2.1 Normal Intervertebral Discs; 4.2.2.2 Disc Alterations in Scoliosis; 4.2.2.3 Intervertebral Disc Characterization In Vivo; 4.3 Biomechanical Modeling and AIS; 4.3.1 Spine Biomechanical Models; 4.3.2 Clinical Relevance of Spine Biomechanical Models; 4.3.2.1 Mechanism of Curve Progression; 4.3.2.2 Modeling of Brace Correction. 4.3.2.3 Modeling of Surgical Correction4.4 Conclusion; References; Chapter 5: Biochemistry of Idiopathic Scoliosis: From Discovery to Diagnostic Biomarkers; 5.1 Introduction; 5.2 Biochemical Factors; 5.2.1 Hormonal Factors; 5.2.1.1 Growth Hormone; 5.2.1.2 Estrogens; 5.2.1.3 Leptin; 5.2.1.4 Ghrelin; 5.2.1.5 Melatonin; 5.2.2 Systemic Factors; 5.2.2.1 G Inhibitory Proteins; 5.2.2.2 Osteopontin; 5.2.3 Hematological factors (Platelet Regulatory Factors); 5.2.3.1 Calmodulin; 5.2.4 Bone Metabolism Factors; 5.2.4.1 Receptor Activator of Nuclear Factor Kappa-B Ligand (RANKL).
• Publisher Details: Tokyo, Japan : Springer
• Publication Date: 2018
• Extent: 1 online resource (ix, 188 pages), illustrations (some color)
• Subjects: 616.7/3; Scoliosis; HEALTH & FITNESS -- Diseases -- General; MEDICAL -- Clinical Medicine; MEDICAL -- Diseases; MEDICAL -- Evidence-Based Medicine; MEDICAL -- Internal Medicine; Scoliosis; Scoliosis -- etiology; Electronic books
• Languages: English
• ISBNs: 9784431565413; 4431565418
• Related ISBNs: 9784431565390; 4431565396
• Notes: Note: Online resource; title from PDF title page (SpringerLink, viewed February 26, 2018).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.