Adult T-cell leukemia/lymphoma. (2017)

• Record Type: Book
• Further Information: Note: Toshiki Watanabe, Takuya Fukushima, editors.
• Editors: Watanabe, Toshiki; Fukushima, Takuya
• Contents: Standardization of Terminology; Formal Name of HTLV-1; Abbreviation of Adult T-Cell Leukaemia-Lymphoma; Contents; Chapter 1: Overview; Chapter 2: Human T-Cell Leukemia Virus Type 1 (HTLV-1); 2.1 Human T-Cell Leukemia Virus Type 1 (HTLV-1) as the First Human Retrovirus; 2.2 Genome Structure and Replication of HTLV-1; 2.2.1 Structural Genes; 2.2.2 Regulatory Proteins: Tax and Rex; 2.2.2.1 Transcriptional Activation of LTR by Tax; 2.2.2.2 Posttranscriptional Regulation of Viral RNA by Rex; 2.2.3 Accessory Proteins: HBZ, p30, p12, p13, and p8. 2.2.3.1 Viral Persistence and HTLV-1-Related Pathogenesis by HBZ2.2.3.2 Posttranscriptional Regulation of Viral and Cellular RNA by p30; 2.2.3.3 Augmentation of Reactive Oxygen Production by p13; 2.2.3.4 Modulation of Signal Transduction and Immune Response by p12/p8; 2.3 Transmission; 2.4 Clonal Expansion and Immune Response; 2.5 Leukemogenesis by Tax and HBZ; 2.5.1 Activation of NF-kappaB; 2.5.2 Activation of the PI3K/AKT Pathway; 2.5.3 Modulation of TGF-beta/Smad and Wnt Signaling Pathways; 2.5.4 Enhancement of S Phase Entry and Cell Cycle Progression. 2.5.5 Induction of Chromosomal Abnormality and DNA Damage2.6 Animal Model; 2.7 Perspective; References; Chapter 3: Epidemiology; 3.1 Introduction; 3.2 Prevalence, Incidence, and Lifetime Risk; 3.2.1 Prevalence and Geographic Distribution of HTLV-1; 3.2.2 Incidence of ATL in the General Population; 3.2.3 Incidence and Lifetime Risk of ATL Among HTLV-1 Carriers; 3.3 Risk Factors for ATL Development from HTLV-1 Carriers; 3.3.1 Host Susceptibility; 3.3.2 Immune System Abnormalities; 3.3.3 Laboratory Markers; 3.3.4 Provirus Load; 3.3.5 Provirus Integration Status. 3.4 Transmission of HTLV-1 and Its Prevention3.4.1 Mother-to-Child Transmission and Its Prevention; 3.4.2 Sexual Transmission and Its Prevention; 3.4.3 Blood-Borne Transmission and Its Prevention; 3.5 Future Perspective; References; Chapter 4: Pathology; 4.1 Neoplastic Lesions; 4.1.1 Sites of Involvement; 4.1.2 Clinical Features: Peripheral Blood; 4.1.3 Lymph Node Lesions; 4.1.3.1 Lymphomatous Lesions; 4.1.3.1.1 Pleomorphic (Medium- and Large-Cell) Type; 4.1.3.1.2 Pleomorphic Small-Cell Type; 4.1.3.1.3 Anaplastic Large-Cell Type; 4.1.3.1.4 AILT-Like ATL. 4.1.3.1.5 Immunophenotypes and Genotypes4.1.3.2 Atypical Lymphomatous and Nonlymphomatous Lesions; 4.1.3.2.1 Hodgkin Cell-Like Type; 4.1.3.2.2 Lymphadenitis Type; 4.1.3.3 Survival Rates; 4.1.4 Cutaneous Lesions; 4.1.5 Gastrointestinal Tract; 4.1.6 Liver; 4.1.7 Bone Marrow; 4.2 Nonneoplastic Lesions; 4.2.1 HTLV-I-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP); 4.2.2 HTLV-I-Associated Uveitis (HAU); 4.2.3 HTLV-I-Associated Bronchopneumopathy or Diffuse Panbronchiolitis (HAB); 4.2.4 Opportunistic Infections; References; Chapter 5: Immunophenotype.
• Publisher Details: Tokyo, Japan : Springer
• Publication Date: 2017
• Extent: 1 online resource (viii, 169 pages), illustrations (some color)
• Subjects: 616.99/419; Adult T-cell leukemia; HTLV-I (Virus); HEALTH & FITNESS -- Diseases -- General; MEDICAL -- Clinical Medicine; MEDICAL -- Diseases; MEDICAL -- Evidence-Based Medicine; MEDICAL -- Internal Medicine; Adult T-cell leukemia; HTLV-I (Virus); Medicine & Public Health; Hematology; Oncology; Infectious Diseases; Immunology; Electronic books
• Languages: English
• ISBNs: 9784431565239
• Related ISBNs: 443156523X; 9784431565215; 4431565213
• Notes: Note: Online resource; title from PDF title page (SpringerLink, viewed May 3, 2017).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.