Penile Cancer : Diagnosis and Treatment.: Diagnosis and Treatment. (2016)

• Record Type: Book
• Other Names: Spiess, Philippe E
• Contents: Intro -- Preface -- Contents -- Abbreviations -- Contributors -- 1: Understanding the Pathophysiology of Penile Cancer and Its Preneoplastic Lesions -- Epidemiology of Penile Cancer -- Risk Factors for Penile Carcinoma -- Pathophysiology -- Human Papillomavirus -- HPV-Mediated Pathway -- HPV-Independent Pathway -- Penile Cancer Precursor Lesions -- Condyloma Acuminatum -- Giant Condyloma Acuminatum (Buschke-Lowenstein Tumor) -- Bowenoid Papulosis -- Lichen Sclerosus (Balanitis Xerotica Obliterans) -- Carcinoma In Situ (Erythroplasia of Queyrat and Bowen's Disease) -- Histologic Subtypes -- Conclusions -- References -- 2: Diagnostic Tools in the Evaluation and Management of Penile Cancer -- Introduction -- Novel Image-Based Diagnostic Tools -- Evaluation and Management of the Primary Penile Lesion -- Evaluation and Management of Loco-Regional Metastatic Lymphatic Spread -- Penile Cancer Biomarkers -- p53 -- p16INK4a -- Ki-67 -- Proliferating Cell Nuclear Antigen -- C-Reactive Protein -- Cyclin D1 -- Other Biomarkers -- Conclusions -- References -- 3: Penile-Sparing Surgical Approaches in the Management of Primary Penile Tumours -- Introduction -- Basis for Penile-Preserving Surgery -- Topical Therapies -- Suitable for Stage Tis Disease Only -- 5 % 5-Fluorouracil (5-FU) -- Imiquimod -- Laser Therapy -- For Stage Tis, But Has Been Used Up to Stage T2 Lesions -- Penile-Sparing Surgical Techniques -- Circumcision -- For Lesions Confined to the Prepuce -- Total Glans Resurfacing -- For Glanular Tis/Ta and Up to Stage T1a Disease -- Partial Glans Resurfacing -- For Isolated Foci of Tis/Ta Affecting < 50 % of Glans -- Moh's Micrographic Surgery -- For Stage T1a, But Has Been Used Up to Stage T3 -- Wide Local Excision/Partial Glansectomy -- For Small, Discrete Lesions on the Glans Up to Stage T1a -- Glansectomy and Reconstruction. For Stage T1b/T2 Tumours Confined to the Glans -- Distal Corporectomy/Partial Penectomy and Reconstruction -- For Stage T2b/Distal T3 Disease -- Conclusions -- References -- 4: Dynamic Sentinel Node Biopsy and FDG-{u00AD}PET/CT for Lymph Node Staging in Penile Cancer -- Introduction -- Risk-Adapted Approach -- Dynamic Sentinel Node Biopsy -- FDG-PET/CT -- Conclusion -- References -- 5: Surgical Decision-Making, Technical Considerations, and Clinical Pearls in Therapeutic Inguinal Node Dissection for Penile Cancer -- Surgical Decision-Making in Patients with CN +ve Penile Cancer -- Unresectable Inguinal Lymphadenopathy -- Role of Systemic Therapy in High-Volume Lymph Node Metastasis -- Technical Considerations Among Patients Undergoing Lymphadenectomy for Clinically Positive Nodes -- Initial Resection of Clinically Mobile Nodes Less Than 4 cm with No Overlying Skin Fixation -- Perioperative Care -- Patient Position -- Skin Incision -- Surgical Boundaries -- Clinically Node Positive Inguinal Field -- Contralateral Clinically Node Negative Inguinal Field -- Indications for Pelvic Lymph Node Dissection -- Special Consideration for Postchemotherapy Resection of Inguinal Metastases -- Surgical Approach and Boundaries -- Myocutaneous Flap and Skin Graft -- Postoperative Care -- Postoperative Complications -- Conclusions -- References -- 6: Minimally Invasive Surgical Approaches to Inguinal Nodes in the Absence of Palpable Adenopathy -- Introduction -- Surgical Technique -- Video Endoscopic Inguinal Lymphadenectomy -- Patient Preparation and Position -- Room Setup -- Trocar Placement -- Anterior Working Space -- Medial and Lateral Boundaries -- Posterior Packet Division and Saphenous Vein Division -- Fossa Ovalis -- Saphenofemoral Vein Dissection and Transection -- Dissection Along the Inguinal Ligament -- Removal of the Packet and Drain Placement. Robot-Assisted Video Endoscopic Inguinal Lymphadenectomy -- Single-Site Video Endoscopic Inguinal Lymphadenectomy -- Saphenous Vein Sparing -- Complications and Morbidity -- References -- 7: Pelvic Lymph Node Dissection for Penile Cancer: Answering the Conundrum of When and How It Should Be Conducted -- Introduction -- Indications -- Surgical Technique -- Unilateral Versus Bilateral PLND -- Systemic Therapy for Pelvic Nodal Disease -- Radiation Therapy for Pelvic Nodal Disease -- Conclusions -- References -- 8: Multimodal Approach to Locally Advanced and Metastatic Penile Cancer -- Introduction -- Locally Advanced and Regionally Metastatic Penile Cancer -- Role of Adjuvant Chemotherapy in Node-Positive Disease -- Role of Postoperative Radiotherapy in Node-Positive Disease -- Multimodal Approach to Bulky, Fixed, or Unresectable Nodal Disease -- Chemoradiotherapy for Locally Advanced Disease -- Future Directions -- HPV and Penile Cancer -- Targeted Therapy for Penile Cancer -- An International Clinical Trial -- Conclusion -- References -- 9: The Role of Radiotherapy in the Management of Penile Cancer -- Introduction -- Radiotherapy for the Primary Tumor -- Carcinoma In Situ (Tis) -- Invasive Cancer -- External Beam Radiotherapy -- Interstitial Low Dose Rate (LDR) Brachytherapy -- High-Dose Rate Interstitial Brachytherapy -- Surface Mold Plesiotherapy -- Patient Selection -- Aftercare -- Late Toxicity -- Regional Radiotherapy -- Combined Chemo-radiotherapy -- Review of the Evidence on the Efficacy of Chemo-radiotherapy from Other SCC Sites -- Head and Neck Cancer -- Anal Canal SCC -- Cervical Cancer -- Vulvar Cancer -- Palliative Treatment -- Conclusions -- References -- 10: New Systemic Approaches and Clinical Trials in Penile Cancer -- Introduction -- Chemotherapy: A Sparse History -- Cisplatin -- Earlier Cisplatin Combinations -- Taxanes. Irinotecan and Gemcitabine -- Intravenous or Intra-arterial Therapy -- Timing Considerations -- Radiation Therapy -- Immunotherapy -- Targeted Pathways -- Contemporary Trials -- Conclusions -- References -- Index.
• Edition: 2nd ed
• Publisher Details: New York, NY : Humana Press
• Publication Date: 2016
• Copyright Date: 2017
• Extent: 1 online resource
• Subjects: 616.99/463; Cancer -- Surgery; Cancer -- Surgery
• Languages: English
• ISBNs: 9781493966790; 1493966790
• Related ISBNs: 9781493966776
• Notes: Note: Description based on publisher supplied metadata and other sources.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.