Cancer drug discovery : science and history /: science and history. (2016)

• Record Type: Book
• Further Information: Note: Kyu-Won Kim, Jae Kyung Roh, Hee-Jun Wee, Chan Kim.
• Authors: Kim, Kyu-Won; Roh, Jae Kyung; (Oncologist), Kim, Chan
• Other Names: Wee, Hee-Jun
• Contents: Part Ⅰ. A Scientific Overview on Cancer.- 1. Advancements in Life Sciences and Characteristic Features of Cancer Cells.- 1.1 Characteristics of cancer cells.- 1.2 Characteristic interactions of cancer cells with neighboring cells and the tumor microenvironment.- 2. Advancement of the Science and History of Cancer and Anticancer Drugs.- Part Ⅱ. Cancer Drug Discovery – Types and History.- 3. Chronology of Anticancer Drug Development.- 3.1 A historical background of cancer chemotherapy.- 3.2 Development of the anticancer drug screening systems.- 3.3 Chronology of the anticancer drug development.- 3.4 Clinical application of anticancer drugs.- 4. Alkylating Anticancer Drugs.- 4.1 Classical alkylating drugs.- 4.2 Nonclassical alkylating drugs.- 4.3 Alkylating-like agents: platinum compounds.- 5. Antimetabolic Anticancer Drugs.- 5.1 Folic acid derivatives.- 5.2 Purine analogs.- 5.3 Pyrimidine analogs.- 6. Natural Product Anticancer Drugs.- 6.1 Plant-derived anticancer drugs.- 6.2 Anticancer antibiotics.- 7. Immunotherapeutic Anticancer Drugs and Other Miscellaneous Anticancer Drugs.- 7.1 Immunotherapeutic anticancer drugs.- 7.2 Other miscellaneous anticancer drugs.- 8. Hormonal Anticancer Drugs.- 8.1 Hormonal anti-prostate-cancer drugs.- 8.2 Hormonal anti-breast-cancer drugs.- 8.3 Other hormonal anticancer drugs.- 9. Molecular Targeted Anticancer Drugs.- 9.1 Tretinoin (all-trans retinoic acid, ATRA).- 9.2 Bcr-Abl Inhibitors.- 9.3 EGFR inhibitors.- 9.4 HER2 inhibitors.- 9.5 Angiogenesis inhibitors.- 9.6 Other kinase inhibitors.- 9.7 mTOR inhibitors.- 9.8 Other targeted anticancer antibody drugs.- 9.9 Epigenetic anticancer drugs.- 9.10 Proteasome inhibitors.- 9.11 Vismodegib: hedgehog pathway blocker.- 10. Complications of Anticancer Drugs and Their Management.- 10.1 Chemotherapy-induced nausea and vomiting (CINV).- 10.2 Myelotoxicity (bone marrow toxicity).- 10.3 Chemotherapy-induced diarrhea.- 10.4 Chemotherapy-induced constipation.- 10.5 Chemotherapy-induced urinary toxicity.- 10.6 Chemotherapy-induced pulmonary toxicity.- 10.7 Chemotherapy-induced neurotoxicity.- 10.8 Chemotherapy-induced neurotoxicity.- 10.9 Chemotherapy-induced oral mucositis.- 10.10 Anorexia.- 10.11 Tumor lysis syndrome.- 10.12 Extravasation of anticancer drugs.- 10.13 Chemotherapy-induced skin toxicity.- Part Ⅲ. A Paradigm Shift in Cancer Research.- 11. Advancements in Bioscience and New Cancer Drugs.- 11.1. Development of cancer drugs according to scientific advancements.- 11.2. New anticancer drugs.
• Publisher Details: Dordrecht : Springer
• Publication Date: 2016
• Copyright Date: 2016
• Extent: 1 online resource (276 pages)
• Subjects: 615.798; Antineoplastic agents -- Development; Cancer -- Chemotherapy
• Languages: English
• ISBNs: 9789402408447
• Related ISBNs: 9789402408423
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.