Percutaneous penetration enhancers drug penetration into/through the skin : methodology and general considerations /: methodology and general considerations. (2017)

• Record Type: Book
• Other Titles: Methodology and general considerations
• Further Information: Note: Nina Dragicevic, Howard I. Maibach, editors.
• Editors: Dragicevic, Nina; Maibach, Howard I
• Contents: Preface; Contents; Contributors; Part I: Factors Influencing Percutaneous Drug Penetration; 1: Basic Mathematics in Skin Absorption; 1.1 Mathematical Background of Analyzing Skin Absorption Processes; 1.2 Analysis of Skin Permeation; 1.2.1 Dealing with Infinite Dose Skin Permeation; 1.2.2 Dealing with Finite Dose Skin Permeation; 1.3 Analysis of Skin Penetration; 1.3.1 Skin-Concentration Depth Profiles; 1.3.2 Skin Compartmental Approaches; 1.4 Advanced Mathematical Approaches for Studying Skin Absorption; 1.4.1 Laplace Domain Solutions; 1.4.2 Numerical Diffusion Models. 1.5 In Vitro-In Vivo Correlation (IVIVC)1.6 Tips and Tricks; 1.6.1 Infinite Sums in Analytical Solutions; 1.6.2 Fitting of Experimental Data; References; 2: Occlusive Versus Nonocclusive Application in Transdermal Drug Delivery; 2.1 Introduction; 2.2 Permeability Barrier of Human Skin; 2.3 Enhancing Effect of Occlusion on Transdermal Delivery; 2.4 Delivery Systems Utilizing the Method of Application; 2.4.1 TransfersomesTM; 2.4.2 Supersaturable Transdermal Delivery Systems; References; 3: Finite and Infinite Dosing; 3.1 Introduction; 3.2 Skin Absorption Kinetics. 3.2.1 Permeation Kinetics3.2.1.1 Infinite-Dose Permeation; 3.2.1.2 Finite-Dose Permeation; 3.2.2 Penetration Kinetics; 3.2.2.1 Infinite-Dose Penetration; 3.2.2.2 Finite-Dose Penetration; References; 4: Non-formulation Parameters That Affect Penetrant-Skin-Vehicle Interactions and Percutaneous Absorption; 4.1 Introduction; 4.2 Skin Responsiveness as It Applies to Targets for Drugs and Cosmetics; 4.3 Structure-Permeation Relationship in Percutaneous Absorption; 4.4 Permeation Through Intact Epidermis; 4.5 Physicochemical Properties That Favour Appendageal Permeation. 4.6 Physicochemical Properties That Favour Direct Subcutaneous and Deeper Tissue Permeation4.7 Skin Hydration and Percutaneous Absorption; 4.8 Age-Related Skin Barrier Performance; 4.9 Site-Related Skin Barrier Performance; 4.10 Gender-Related Skin Barrier Performance; 4.11 Barrier Performance in Cosmetically Treated Skin; 4.11.1 Insect Repellents; 4.11.2 Chemical Depilatories; 4.11.3 Peeling Agents; 4.11.4 Other Cosmetic Products; 4.12 Compromised Barrier Performance; 4.12.1 Intrinsic Barrier Defects; 4.12.2 Thermally Damaged Skin and Its Manipulation. 4.13 Prevention of Percutaneous Permeation: A Possibility and a NecessityReferences; 5: The Influence of Emollients on Dermal and Transdermal Drug Delivery; 5.1 Introduction; 5.2 Current Emollients, Their Modes of Action, and Their Use in Practice; 5.2.1 Sebum; 5.2.2 Emollient Classes and Properties; 5.2.3 Effect of Emollients on Skin Lubrication; 5.2.4 Effect of Emollients on Skin TEWL and Skin Hydration; 5.2.5 Emollient Substantivity; 5.2.6 An Overall Comparison of Emollient Properties; 5.3 Effects of Emollients on Percutaneous Absorption.
• Publisher Details: Berlin, Germany : Springer
• Publication Date: 2017
• Extent: 1 online resource (xvi, 414 pages), illustrations (some color)
• Subjects: 615.7/78; Dermatologic agents -- Absorption and adsorption; Drug delivery systems; MEDICAL -- Pharmacology; Dermatologic agents -- Absorption and adsorption; Drug delivery systems; Administration, Cutaneous; Electronic books; Electronic book
• Languages: English
• ISBNs: 9783662532706; 3662532700
• Related ISBNs: 9783662532683; 3662532689
• Notes: Note: Includes bibliographical references and index.; Note: Online resource; title from PDF title page (SpringerLink, viewed May 11, 2017).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.