Predictive methods in percutaneous absorption. (2015)

• Record Type: Book
• Further Information: Note: Gary P. Moss, Darren R. Gullick, Simon C. Wilkinson.
• Authors: Moss, Gary P; Gullick, Darren R; Wilkinson, Simon C
• Contents: Foreword; Acknowledgments; Contents; 1 Skin Structure and Physiology; Introduction; The Hypodermis (Subcutaneous Fatty Tissue Layer); The Dermis; Skin Appendages; The Subcutaneous Sensory Mechanism; The Epidermis; The Stratum Germinativum; The Stratum Spinosum; The Stratum Granulosum; The Stratum Lucidum; The Stratum Corneum; The Stratum Corneum Barrier; Routes of Permeation of Exogenous Chemicals Across the Stratum Corneum; Percutaneous Permeation -- Mechanisms of Absorption; Theoretical Considerations; Physicochemical Properties of the Penetrant; Partition Coefficient. Molecular Size and ShapeApplied Concentration/Dose; Aqueous Solubility and Melting Point; Ionisation; Physiological Factors Affecting Percutaneous Absorption; Skin Condition; Skin Hydration and Occlusion; Skin Age; Site-to-Site Variation; Race; Skin Temperature; Vehicle Effects; References; 2 Methods for the Measurement of Percutaneous Absorption; Introduction; In Vivo and In Vitro Methods: Overview; In Vitro Experimental Methods; Preamble; Membrane Selection; Integrity Testing; Selection of the Diffusion Cell Apparatus; Temperature; Formulation and Solubility Factors. Detection of the PermeantConclusions; References; 3 Mathematical Treatments and Early Models of Skin Permeability; Introduction; Infinite and Finite Dosing; References; 4 The New Breadth of Research in the Field; References; 5 Algorithms for Estimating Permeability Across Artificial Membranes; The Role of Artificial Membranes in Studies of Percutaneous Absorption; Quantitative Models for Permeability Across Polydimethylsiloxane Membranes; References; 6 Other Approaches to Modelling Percutaneous Absorption; References. 7 Squiggly Lines and Random Dots -- You Can Fit Anything with a Nonlinear ModelIntroduction; Application of a Nonlinear Multiple Regression Model to Skin Permeability; Fuzzy Logic and Neural Network Methods for the Prediction of Skin Permeability; More Machine Learning Methods -- Classification and Gaussian Process Models; References; 8 Finite-Dose Models of Transient Exposures and Volatile Formulation Components; Introduction; Modelling Finite-Dose Experiments; Models of Formulation in Finite-Dose Experiments; Conclusions; References; 9 The Devil is in the Detail2026; Introduction. Experimental Factors in Model QualityAnalysis of the Experiments from Which Data Have Been Taken to Develop Models of Skin Absorption; Formulation Factors; Conclusions; References; 10 Conclusions and Recommendations for Model Development and Use; Overview of the Previous Chapters; ``Pitfalls'' of Model Development and Use; Quality of the Source, or Input, Data; Outliers; Biological Data; Descriptor Selection and Interpretation, and Data Set Design; Statistical Analysis of Data; Data -- and Data Set -- Quality; Conclusions; References; Index.
• Publisher Details: Heidelberg : Springer
• Publication Date: 2015
• Extent: 1 online resource (xv, 199 pages), illustrations (some color)
• Subjects: 612.7/9015118; Skin absorption -- Mathematical models; Skin absorption -- Computer simulation; MEDICAL -- Physiology; SCIENCE -- Life Sciences -- Human Anatomy & Physiology; Skin absorption -- Mathematical models; Biomedicine; Pharmacology/Toxicology; Human Physiology; Dermatology; Physiological, Cellular and Medical Topics; Skin Absorption; Electronic books
• Languages: English
• ISBNs: 9783662473719; 3662473712; 3662473704; 9783662473702
• Related ISBNs: 9783662473702
• Notes: Note: Includes bibliographical references and index.; Note: Online resource; title from PDF title page (SpringerLink, viewed July 8, 2015).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.